ArticleJournal of neurophysiology2006
Interneuron and pyramidal cell interplay during in vitro seizure-like events.
Article in Journal of neurophysiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 147 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
147 citing papers in PubMed, 1 synthesis or guideline pooled it, 295 citations in OpenAlex.
- GABAFrontiers in neural circuits · 2022Pooled it
- Laminar organization of cellular microcircuits modulating human interictal epileptiform discharges.Nature neuroscience · 2026Article
- Heterogeneity of ictal firing during generalized seizures in the awake cortex.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Tsunamis hiding in plain sight: spreading depression in clinical neurology.Nature reviews. Neurology · 2026Review
- Electrophysiologically Targeted Biopsies Reveal the Transcriptional Landscape of Focal Epilepsy.bioRxiv : the preprint server for biology · 2026Article
- Review
- Use-dependent regulation of the axonal action potential in parvalbumin-expressing interneurons.bioRxiv : the preprint server for biology · 2026Article
- Harmonic patterns embedded in ictal EEG signals in focal epilepsy: new insight into the epileptogenic zone.BMC medicine · 2026Article
- Depolarization block induction via slow NaScientific reports · 2025Article
- Functional Alterations in Parvalbumin-Positive Interneurons after Traumatic Brain Injury in Somatosensory Cortex of Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Interneuron-Driven Ictogenesis in the 4-Aminopyridine Model: Depolarization Block and Potassium Accumulation Initiate Seizure-like Activity.International journal of molecular sciences · 2025Article
- Downmodulation of Potassium Conductances Induces Epileptic Seizures in Cortical Network Models Via Multiple Synergistic Factors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Dynamics and conditions for inhibitory synaptic current to induce bursting and spreading depolarization in pyramidal neurons.Scientific reports · 2025Article
- Preictal connectivity dynamics: Exploring inflow and outflow in iEEG networks.Frontiers in network physiology · 2025Article
- Parvalbumin interneuron impairment causes synaptic transmission deficits and seizures in SCN8A developmental and epileptic encephalopathy.JCI insight · 2024Article
- Article
- Multistability of bursting rhythms in a half-center oscillator and the protective effects of synaptic inhibition.Frontiers in cellular neuroscience · 2024Article
- Evaluating cortical excitatory and inhibitory activity through interictal intracranial electroencephalography in mesial temporal lobe epilepsy.Frontiers in neuroscience · 2024Article
- Cell-type specific and multiscale dynamics of human focal seizures in limbic structures.Brain : a journal of neurology · 2023Article
- Bursting Dynamics Based on the Persistent NaeNeuro · 2023Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Excitatory and inhibitory (EI) interactions shape network activity. However, little is known about the EI interactions in pathological conditions such as epilepsy. To investigate EI interactions during seizure-like events (SLEs), we performed simultaneous dual and triple whole cell and extracellular recordings in pyramidal cells and oriens interneurons in rat hippocampal CA1. We describe a novel pattern of interleaving EI activity during spontaneous in vitro SLEs generated by the potassium channel blocker 4-aminopyridine in the presence of decreased magnesium. Interneuron activity was increased during interictal periods. During ictal discharges interneurons entered into long-lasting depolarization block (DB) with suppression of spike generation; simultaneously, pyramidal cells produced spike trains with increased frequency (6-14 Hz) and correlation. After this period of runaway excitation, interneuron postictal spiking resumed and pyramidal cells became progressively quiescent. We performed correlation measures of cell-pair interactions using either the spikes alone or the subthreshold postsynaptic interspike signals. EE spike correlation was notably increased during interneuron DB, whereas subthreshold EE correlation decreased. EI spike correlations increased at the end of SLEs, whereas II subthreshold correlations increased during DB. Our findings underscore the importance of complex cell-type-specific neuronal interactions in the formation of seizure patterns.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.