ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Retinoic acid receptor-dependent survival of olfactory sensory neurons in postnatal and adult mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 51 citations in OpenAlex.
- Dietary vitamin A restricts intestinal tuft cell differentiation.Cell reports · 2026Article
- Vitamin A-Containing Intranasal Drops Improve Odour Detection Threshold.ORL; journal for oto-rhino-laryngology and its related specialties · 2026Article
- A spatial code governs olfactory receptor choice and aligns sensory maps in the nose and brain.Cell · 2026Article
- Why Does the Face Predict the Brain? Neural Crest Induction, Craniofacial Morphogenesis, and Neural Circuit Development.Frontiers in physiology · 2020Review
- Intranasal vitamin A is beneficial in post-infectious olfactory loss.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Article
- Deletion of Type 3 Adenylyl Cyclase Perturbs the Postnatal Maturation of Olfactory Sensory Neurons and Olfactory Cilium Ultrastructure in Mice.Frontiers in cellular neuroscience · 2017Article
- Differential Regulation of Bcl-xL Gene Expression by Corticosterone, Progesterone, and Retinoic Acid.Journal of biochemical and molecular toxicology · 2016Article
- Article
- Zebrafish cerebrospinal fluid mediates cell survival through a retinoid signaling pathway.Developmental neurobiology · 2016Article
- The Stimulus-Dependent Gradient of Cyp26B1+ Olfactory Sensory Neurons Is Necessary for the Functional Integrity of the Olfactory Sensory Map.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Temporal changes of cytochrome P450 (Cyp) and eicosanoid-related gene expression in the rat brain after traumatic brain injury.BMC genomics · 2013Article
- Differential expression of components of the retinoic acid signaling pathway in the adult mouse olfactory epithelium.The Journal of comparative neurology · 2012Article
- Visualization of retinoic acid signaling in transgenic axolotls during limb development and regeneration.Developmental biology · 2012Article
- Retinoic acid receptor and CNGA2 channel signaling are part of a regulatory feedback loop controlling axonal convergence and survival of olfactory sensory neurons.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Uncx regulates proliferation of neural progenitor cells and neuronal survival in the olfactory epithelium.Molecular and cellular neurosciences · 2010Article
- Retinoic acid receptor-α signalling antagonizes both intracellular and extracellular amyloid-β production and prevents neuronal cell death caused by amyloid-β.The European journal of neuroscience · 2010Article
- Long-term survival of olfactory sensory neurons after target depletion.The Journal of comparative neurology · 2009Article
- Retinoic acid is present in the postnatal rat olfactory organ and persists in vitamin A--depleted neural tissue.The Journal of nutrition · 2009Article
- Neuropathology of the olfactory mucosa in chronic rhinosinusitis.American journal of rhinology & allergyArticle
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To address the hypothesis that retinoids produced by synthesizing enzymes present in the primary olfactory system influence the mouse olfactory sensory map, we expressed a dominant-negative retinoic acid receptor selectively in olfactory sensory neurons. We show that neurons deficient in nuclear retinoid signaling are responsive to odors and form correct odorant receptor-specific axonal projections to target neurons in the olfactory bulb of the brain. Subsequent to the formation of the map, the neurons die prematurely by retrograde-driven caspase-3 activation, which resembles the previously described mechanism of neural death after olfactory bulb ablation. This neurodegenerative event is initiated the second postnatal week and occurs in the adult animal without a compensatory increase of progenitor cell proliferation. In addition, we find that nuclear retinoid signaling is required for the expression of a retinoic acid-degrading enzyme, Cyp26B1, in a small fraction of mature neurons. Collectively, the results provide evidence for a role of locally regulated retinoid metabolism in neuroprotection and in determining population size of neurons at a late stage of neural circuit formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.