ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Dopaminergic regulation of neuronal excitability through modulation of Ih in layer V entorhinal cortex.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed, 114 citations in OpenAlex.
- Resonant hierarchies: a multiscale framework for oscillatory dynamics in the brain.Frontiers in psychology · 2026Article
- In silico investigation of the puzzling dopamine effects on excitability and synaptic plasticity in hippocampal CA1 pyramidal neurons.Scientific reports · 2025Article
- Nonlinear high-activity neuronal excitation enhances odor discrimination.Current biology : CB · 2025Article
- Review
- Emergence of stochastic resonance in a two-compartment hippocampal pyramidal neuron model.Journal of computational neuroscience · 2022Article
- Active Dendrites and Local Field Potentials: Biophysical Mechanisms and Computational Explorations.Neuroscience · 2022Review
- Navigating for reward.Nature reviews. Neuroscience · 2021Review
- Ion-channel degeneracy: Multiple ion channels heterogeneously regulate intrinsic physiology of rat hippocampal granule cells.Physiological reports · 2021Article
- Dopamine Modulation of Motor and Sensory Cortical Plasticity among Vertebrates.Integrative and comparative biology · 2021Review
- Neuromodulation of Astrocytic KInternational journal of molecular sciences · 2021Article
- The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function.Journal of neuroinflammation · 2020Article
- Dopaminergic Modulation of Signal Processing in a Subset of Retinal Bipolar Cells.Frontiers in cellular neuroscience · 2020Article
- Lack of experience-dependent intrinsic plasticity in the adolescent infralimbic medial prefrontal cortex.Synapse (New York, N.Y.) · 2019Article
- Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?Frontiers in molecular neuroscience · 2019Article
- Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via βFrontiers in cellular neuroscience · 2017Article
- Does Epileptiform Activity Represent a Failure of Neuromodulation to Control Central Pattern Generator-Like Neocortical Behavior?Frontiers in neural circuits · 2017Article
- Heterosynaptic modulation of evoked synaptic potentials in layer II of the entorhinal cortex by activation of the parasubiculum.Journal of neurophysiology · 2016Article
- mGlu1 receptor mediates homeostatic control of intrinsic excitability through Ih in cerebellar Purkinje cells.Journal of neurophysiology · 2016Article
- Methamphetamine blunts Ca(2+) currents and excitatory synaptic transmission through D1/5 receptor-mediated mechanisms in the mouse medial prefrontal cortex.Addiction biology · 2016Article
- Superficial Layer-Specific Histaminergic Modulation of Medial Entorhinal Cortex Required for Spatial Learning.Cerebral cortex (New York, N.Y. : 1991) · 2016Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The entorhinal cortex (EC) is a significant component of the systems that underlie certain forms of memory formation and recall. Evidence has been emerging that the dopaminergic system in the EC facilitates these and other functions of the EC. The effects of dopamine (DA) on membrane properties and excitability of EC neurons, however, are not known. We used in vitro whole-cell patch-clamp recordings from layer V pyramidal neuronal somata and dendrites of the adult rat lateral EC to investigate the effects of DA on the excitability of these neurons. We found that brief application of DA caused a reduction in the excitability of layer V EC pyramidal neurons. This effect was attributable to voltage-dependent modification of membrane properties that can best be explained by an increase in a hyperpolarization-activated conductance. Furthermore, the effects of DA were blocked by pharmacological blockade of h-channels, but not by any of a number of other ion channels. These actions were produced by a D1 receptor-mediated increase of cAMP but were independent of protein kinase A. A portion of the actions of DA can be attributed to effects in the apical dendrites. The data suggest that DA can directly influence the membrane properties of layer V EC pyramidal neurons by modulation of h-channels. These actions may underlie some of the effects of DA on memory formation.
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