ArticleBMJ (Clinical research ed.)2006
Parenteral penicillin for children with meningococcal disease before hospital admission: case-control study.
Article in BMJ (Clinical research ed.), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 4 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Osmotic therapies added to antibiotics for acute bacterial meningitis.The Cochrane database of systematic reviews · 2018Pooled it
- Pre-admission antibiotics for suspected cases of meningococcal disease.The Cochrane database of systematic reviews · 2017Pooled it
- Osmotic therapies added to antibiotics for acute bacterial meningitis.The Cochrane database of systematic reviews · 2013Pooled it
- Effectiveness of antibiotics given before admission in reducing mortality from meningococcal disease: systematic review.BMJ (Clinical research ed.) · 2006Pooled it
- Article
- Prevalence, Characteristics, and Determinants of Suboptimal Care in the Initial Management of Community-Onset Severe Bacterial Infections in Children.JAMA network open · 2022Article
- Impact of pre-hospital antibiotic therapy on mortality in invasive meningococcal disease: a propensity score study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Observational
- Goal directed therapy for suspected acute bacterial meningitis in adults and adolescents in sub-Saharan Africa.PloS one · 2017Article
- Time to antibiotic therapy and outcome in bacterial meningitis: a Danish population-based cohort study.BMC infectious diseases · 2016Article
- High mortality amongst adolescents and adults with bacterial meningitis in sub-Saharan Africa: an analysis of 715 cases from Malawi.PloS one · 2013Article
- Suspicion and treatment of severe sepsis. An overview of the prehospital chain of care.Scandinavian journal of trauma, resuscitation and emergency medicine · 2012Review
- Meningococcal disease and its management in children.BMJ (Clinical research ed.) · 2006Review
- Prehospital parenteral penicillin for meningitis: Urgent review of treatment criteria is needed.BMJ (Clinical research ed.) · 2006Article
- Prehospital parenteral penicillin for meningitis: Trial in children with suspected meningococcal disease would be useful.BMJ (Clinical research ed.) · 2006Article
- Statistics and death from meningococcal disease in children.BMJ (Clinical research ed.) · 2006Article
- Parenteral penicillin before admission to hospital for meningitis.BMJ (Clinical research ed.) · 2006Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo explore the impact on mortality and morbidity of parenteral penicillin given to children before admission to hospital with suspected meningococcal disease.
designRetrospective comparison of fatal and non-fatal cases.
settingEngland, Wales, and Northern Ireland; December 1997 to February 1999.
participants158 children aged 0-16 years (26 died, 132 survived) in whom a general practitioner had made the diagnosis of meningococcal disease before hospital admission.
resultsAdministration of parenteral penicillin by general practitioners was associated with increased odds ratios for death (7.4, 95% confidence interval 1.5 to 37.7) and complications in survivors (5.0, 1.7 to 15.0). Children who received penicillin had more severe disease on admission (median Glasgow meningococcal septicaemia prognostic score (GMSPS) 6.5 v 4.0, P = 0.002). Severity on admission did not differ significantly with time taken to reach hospital.
conclusionsChildren who were given parenteral penicillin by a general practitioner had more severe disease on reaching hospital than those who were not given penicillin before admission. The association with poor outcome may be because children who are more severely ill are being given penicillin before admission.
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