ArticleWorld journal of gastroenterology2006
Evaluation of p53 codon 72 polymorphism in adenocarcinomas of the colon and rectum in La Plata, Argentina.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- The association between the TP53 Arg72Pro polymorphism and colorectal cancer: An updated meta-analysis based on 32 studies.Oncotarget · 2017Pooled it
- Systematic meta-analyses and field synopsis of genetic association studies in colorectal adenomas.International journal of epidemiology · 2016Pooled it
- TP53 codon 72 polymorphism and colorectal cancer susceptibility: a meta-analysis.Molecular biology reports · 2011Pooled it
- Association betweenIranian journal of public health · 2025Review
- Association ofAfrican health sciences · 2022Article
- TP53 Codon 72 Polymorphism and the Risk of Colorectal Cancer in an Azerbaijani Population.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2022Article
- Risk of Colorectal Carcinoma May Predispose to the Genetic Variants of theInternational journal of general medicine · 2021Article
- Dynamic role of the codon 72 p53 single-nucleotide polymorphism in mammary tumorigenesis in a humanized mouse model.Oncogene · 2019Article
- Five P53 SNPs Involved in Low Rectal Cancer Risk and Prognosis in a Chinese Population.Journal of Cancer · 2019Article
- Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population.Current genomics · 2018Article
- TP53 Gene Pro72Arg (rs1042522) Single Nucleotide Polymorphism as Not a Risk Factor for Colorectal Cancer in the Iranian Azari PopulationAsian Pacific journal of cancer prevention : APJCP · 2017Article
- Genetic polymorphisms of superoxide dismutase-1 A251G and catalase C-262T with the risk of colorectal cancer.Molecular biology research communications · 2017Article
- State of Art of Cancer Pharmacogenomics in Latin American Populations.International journal of molecular sciences · 2017Review
- Breast cancer risk in relation to TP53 codon 72 and CDH1 gene polymorphisms in the Bangladeshi women.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- TP53 Polymorphisms and Colorectal Cancer Risk in Patients with Lynch Syndrome in Taiwan: A Retrospective Cohort Study.PloS one · 2016Article
- TP53 codon 72 Arg/Arg polymorphism is associated with a higher risk for inflammatory bowel disease development.World journal of gastroenterology · 2015Article
- Association of p53 rs1042522, MDM2 rs2279744, and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population.Scientific reports · 2015Article
- TP53 Arg 72Pro and MDM2 SNP309 polymorphisms and colorectal cancer risk: a west Algerian population study.Pathology oncology research : POR · 2015Article
- Survivin: A molecular biomarker in cancer.The Indian journal of medical research · 2015Review
- TP53 alterations and colorectal cancer predisposition in south Indian population: a case-control study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
Corrections and comments
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the potential association between p53 codon 72 polymorphism and sporadic colorectal adenocarcinoma development,and human papillomavirus (HPV) infection.
methodsOne-hundred and nine controls and 53 patients with colon cancer from the city of La Plata, Argentina were analyzed. p53 codon 72 genotypes and HPV infection were identified using allele-specific polymerase chain reaction and nested polymerase chain reaction, respectively.
resultsThe differences in the distribution of p53 codon 72 polymorphism between the cases and controls were statistically significant. The arginine allele had a prevalence of 0.65 in controls and 0.77 in cases. The corresponding odds ratio for the homozygous arginine genotype was 2.08 (95% CI, 1.06-4.05; P<0.05). Lack of association was found between p53 polymorphism and HPV infection in the set of adenocarcinomas.
conclusionThe findings of the present study indicate that p53 codon 72 arginine homozygous genotype may represent a genetic predisposing factor for colon cancer development. However,further studies are needed in order to elucidate the role of p53 codon 72 polymorphism in colorectal cancer.
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