ArticleCell and tissue research1991
Changes in glial fibrillary acidic protein and karyotype during culturing of two cell lines established from human glioblastoma multiforme.
Article in Cell and tissue research, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The Flavonoid Rutin Enhances Temozolomide Sensitivity in Glioblastoma Spheroids by Modulating Chemoresistance via PI3K/AKT, STAT3, Redox and Kynurenine Pathways, and Altering ECM Remodeling Associated with Reduced Migration.Antioxidants (Basel, Switzerland) · 2026Article
- Agathisflavone Inhibits Viability and Modulates the Expression of miR-125b, miR-155, IL-6, and Arginase in Glioblastoma Cells and Microglia/Macrophage Activation.Molecules (Basel, Switzerland) · 2025Article
- Flavonoid Rutin Presented Anti-Glioblastoma Activity Related to the Modulation of Onco miRNA-125b Expression and STAT3 Signaling and Impact on Microglia Inflammatory Profile.Brain sciences · 2024Article
- Establishment and characteristics of GWH04, a new primary human glioblastoma cell line.International journal of oncology · 2022Article
- Effect of 1α,25(OH)Cancers · 2020Article
- Impact of Hypoxia on Carbon Ion Therapy in Glioblastoma Cells: Modulation by LET and Hypoxia-Dependent Genes.Cancers · 2020Article
- CRMP2 Phosphorylation Drives Glioblastoma Cell Proliferation.Molecular neurobiology · 2018Article
- Transcriptional regulation of CRMP5 controls neurite outgrowth through Sox5.Cellular and molecular life sciences : CMLS · 2018Article
- Signaling switch of the urotensin II vasosactive peptide GPCR: prototypic chemotaxic mechanism in glioma.Oncogene · 2015Article
- Identifying the optimal dose of ritonavir in the treatment of malignancies.Metabolic brain disease · 2014Article
- 8-Methoxypsoralen is a competitive inhibitor of glutathione S-transferase P1-1.Frontiers in cellular neuroscience · 2014Article
- Functional cross talk between CXCR4 and PDGFR on glioblastoma cells is essential for migration.PloS one · 2013Article
- Human glioma cell culture: two FCS-free media could be recommended for clinical use in immunotherapy.In vitro cellular & developmental biology. Animal · 2009Article
- S100B Protein Regulates Astrocyte Shape and Migration via Interaction with Src Kinase: IMPLICATIONS FOR ASTROCYTE DEVELOPMENT, ACTIVATION, AND TUMOR GROWTH.The Journal of biological chemistry · 2009Article
- Contribution of gap junctional communication between tumor cells and astroglia to the invasion of the brain parenchyma by human glioblastomas.BMC cell biology · 2005Article
- Multidrug resistance-associated protein MRP1 expression in human gliomas: chemosensitization to vincristine and etoposide by indomethacin in human glioma cell lines overexpressing MRP1.Journal of neuro-oncology · 2004Article
- Migration pathways of human glioblastoma cells xenografted into the immunosuppressed rat brain.Journal of neuro-oncology · 2001Article
- Identification of uncommon chromosomal aberrations in the neuroglioma cell line H4 by spectral karyotyping.Journal of neuro-oncology · 2001Article
- Calcium-mediated transductive systems and functionally active gap junctions in astrocyte-like GL15 cells.BMC physiology · 2001Article
- Improved technique for establishing short term human brain tumor cultures.Journal of neuro-oncology · 1999Article
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5 authors.
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Abstract
Two human cell lines (GL15 and GL22) derived from glioblastoma multiforme were established and characterized by immunohistochemical and cytogenetic techniques. The expression of glial fibrillary acidic proteins and the karyotype were analyzed at different passages for both cell lines. The course of marker-pattern differed in the two cell lines. The main findings were a cell-density-dependent expression of glial fibrillary acidic protein in the cell line GL15 at all passages and a decreased expression of this protein over time in the cell line GL22. Both cell lines had hyperdiploid karyotypes and exhibited glioma-specific chromosomal abnormalities (gain of chromosome 7 and loss of chromosome 10). In the GL15 cell line no relevant chromosomal changes were produced during culturing, whereas in the GL22 cell line a hypodiploid clone appeared at the 42nd passage. The immunohistochemical and cytogenetic data resulting from this study confirm that the two cell lines established in our laboratory originated from astrocytic tumor cells.
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