ArticleJournal of neuro-oncology2006
Central neurocytomas with MIB-1 labeling index over 10% showing rapid tumor growth and dissemination.
Article in Journal of neuro-oncology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 34 citations in OpenAlex.
- The role of single fraction Gamma Knife radiosurgery for intraventricular central neurocytomas and the utility of F-18 fluroethyltyrosine: two case reports.Journal of medical case reports · 2022Article
- The role of methylation profiling in histologically diagnosed neurocytoma: a case series.Journal of neuro-oncology · 2022Article
- Malignant transformation of central neurocytoma with dissemination 17 years after initial treatment: illustrative case.Journal of neurosurgery. Case lessons · 2022Article
- Individual Treatment Decisions for Central Neurocytoma.Frontiers in neurology · 2020Article
- The role of chemotherapy in the treatment of central neurocytoma.CNS oncology · 2019Review
- Article
- Clinical course of central neurocytoma with malignant transformation-an indication for craniospinal irradiation.Pathology oncology research : POR · 2014Article
- Extraventricular neurocytoma in pediatric populations: A case report and review of the literature.Oncology letters · 2013Article
- MIB-1 labeling index predicts recurrence in intraventricular central neurocytomas.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2013Article
- Primary disseminated central neurocytoma: cytological and MRI evidence of tumor spread prior to surgery.Journal of neuro-oncology · 2010Article
- Treatment of atypical central neurocytoma in a child with high dose chemotherapy and autologous stem cell rescue.Journal of neuro-oncology · 2010Article
- Intracranial dissemination from spinal cord anaplastic astrocytoma.Journal of Korean Neurosurgical Society · 2010Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objective and importanceCentral neurocytoma is recognized as a indolent intraventricular tumor arising from the ependyma around the foramen of Monro and anterior part of the lateral ventricles, and well demarcated from the brain parenchyma. Surgical removal can be curative without postoperative therapy. However, malignant central neurocytoma refractory to even aggressive treatment is known. CLINICAL PRESENTATION: We report two cases of extraventricular central neurocytomas with significant vascular proliferation, mitoses, and MIB-1 labeling index of more than 10%.
interventionSubtotal removal for the one patient and open biopsy for other followed by radiotherapy with chemotherapy were performed. However, the disease progressed and dissemination occurred. Both patients subsequently died 23 and 18 month after the histological diagnosis was established.
conclusionExtraventricular central neurocytoma may present with frequent vascular proliferation and high MIB-1 labeling index. Even if they lack malignant histological findings like frequent mitosis and/or necrosis, the prognosis for such patients is very poor.
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