ArticleCurrent genetics2006
Roles of the RAM signaling network in cell cycle progression in Saccharomyces cerevisiae.
Article in Current genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 27 citations in OpenAlex.
- The MO25 protein Pmo25 functions in contractile ring stability and Sid2 localization during cytokinesis.iScience · 2026Article
- Roles of the MO25 protein Pmo25 in contractile-ring stability and localization of the NDR kinase Sid2 during cytokinesis.bioRxiv : the preprint server for biology · 2025Article
- A conserved fungal morphogenetic kinase regulates pathogenic growth in response to carbon source diversity.Nature communications · 2024Article
- Rapid evolution of an adaptive multicellular morphology of Candida auris during systemic infection.Nature communications · 2024Article
- The Cbk1-Ace2 axis guides Candida albicans from yeast to hyphae and back again.Current genetics · 2021Article
- Perturbations of Transcription and Gene Expression-Associated Processes Alter Distribution of Cell Size Values inG3 (Bethesda, Md.) · 2019Article
- Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment.Structure (London, England : 1993) · 2018Article
- Meiotic Interactors of a Mitotic Gene TAO3 Revealed by Functional Analysis of its Rare Variant.G3 (Bethesda, Md.) · 2016Article
- Morphology and its underlying genetic regulation impact the interaction between Cryptococcus neoformans and its hosts.Medical mycology · 2015Article
- Cell cycle regulated interaction of a yeast Hippo kinase and its activator MO25/Hym1.PloS one · 2013Article
- Mitotic exit and separation of mother and daughter cells.Genetics · 2012Review
- The RAM network in pathogenic fungi.Eukaryotic cell · 2012Review
- Mutations in the RAM network confer resistance to the thiol oxidant 4,4'-dipyridyl disulfide.Molecular genetics and genomics : MGG · 2008Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The Saccharomyces cerevisiae Hym1p, Mob2p, Tao3p, Cbk1p, Sog2p and Kic1p proteins are thought to function together in the RAM signaling network, which controls polarized growth, cell separation and cell integrity. Whether these proteins also function as a network to affect cell proliferation is not clear. Here we examined cells lacking or over-expressing RAM components, and evaluated the timing of initiation of DNA replication in each case. Our results suggest opposing roles of RAM proteins, where only Hym1p can promote the transition from the G1 to S phase of the cell cycle. We also uncovered additive growth defects in strains lacking several pair-wise combinations of RAM proteins, possibly arguing for multiple roles of RAM components in the overall control of cell proliferation. Finally, our findings suggest that Hym1p requires the Dcr2p phosphatase to promote the G1/S transition, but it does not require the G1 cyclin Cln3p or the RAS pathway. Taken together, our results point to a complex regulation of cell proliferation by RAM proteins, in a non-uniform manner that was not previously anticipated.
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