ArticleMycopathologia2006
Inhibition of nitric oxide production by macrophages in chromoblastomycosis: a role for Fonsecaea pedrosoi melanin.
Article in Mycopathologia, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 58 citations in OpenAlex.
- Tricyclazole alleviatesFrontiers in cellular and infection microbiology · 2025Article
- Melanin Synthesized by the EndophyticCurrent topics in medicinal chemistry · 2024Article
- Silver(I) 1,10-Phenanthroline Complexes Are Active againstJournal of fungi (Basel, Switzerland) · 2023Article
- Expanding the Toolbox for Functional Genomics inJournal of fungi (Basel, Switzerland) · 2023Article
- An Experimental Model of Chromoblastomycosis Caused by Fonsecaea sp. Species.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Pathogenicity and Growth Conditions ModulateFrontiers in cellular and infection microbiology · 2022Article
- Neutrophil-suppressive activity over T-cell proliferation and fungal clearance in a murine model of Fonsecaea pedrosoi infection.Scientific reports · 2021Article
- Sporothrix globosa melanin inhibits antigenpresentation by macrophages and enhances deep organ dissemination.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Article
- Reviewing the Etiologic Agents, Microbe-Host Relationship, Immune Response, Diagnosis, and Treatment in Chromoblastomycosis.Journal of immunology research · 2021Review
- Immune Sensing and Potential Immunotherapeutic Approaches to Control Chromoblastomycosis.Journal of fungi (Basel, Switzerland) · 2020Review
- Biological activities of melanin pigment extracted from Bombyx mori gut-associated yeast Cryptococcus rajasthanensis KY627764.World journal of microbiology & biotechnology · 2020Article
- Fonsecaea pedrosoi Conidia Induces Activation of Dendritic Cells and Increases CD11cMycopathologia · 2020Article
- Genomics and Virulence ofFrontiers in genetics · 2020Article
- Article
- Modulation of the immune response by Fonsecaea pedrosoi morphotypes in the course of experimental chromoblastomycosis and their role on inflammatory response chronicity.PLoS neglected tropical diseases · 2017Article
- The Major Chromoblastomycosis Etiologic AgentFrontiers in immunology · 2017Article
- HIV Aspartic Peptidase Inhibitors Modulate Surface Molecules and Enzyme Activities Involved with Physiopathological Events inFrontiers in microbiology · 2017Article
- Chromoblastomycosis.Clinical microbiology reviews · 2017Review
- Chromoblastomycosis.Postepy dermatologii i alergologii · 2014Review
- Association of IgG immunoglobulin and subclasses level with the severity of chromoblastomycosis due to Fonsecaea pedrosoi and therapeutic response to itraconazole.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chromoblastomycosis is a chronic and progressive deep mycosis that is usually found in tropical and subtropical areas. Fonsecaea pedrosoi is considered its most frequent etiologic agent and causes a typical granulomatous inflammatory response, whose degree reflects the immune status of the host. Since macrophages play a fundamental role in the control of the infection, this study aimed at investigating the production of oxygen reactive specimens, the phagocytic capacity and the production of nitric oxide (NO) by macrophages employing in vitro assays and an in vivo model of chromoblastomycosis. Our results demonstrated that, during the infection, peritoneal macrophages show an increased phagocytic capacity and H2O2 production, but also a reduced ability to produce NO. Moreover, F. pedrosoi stimulated H2O2 production in vitro but not the synthesis of NO. The incubation of IFNgamma and LPS-stimulated macrophages with melanin, obtained from the fungus, inhibited NO production. Examination of the liver and spleen of infected animals, at day 30 or 60 following inoculation, showed a progressive increase in the number and size of granulomas, indicating that macrophages are properly mobilized and activated. Our data suggest that the inability of the host to clear F. pedrosoi, leading to a chronic disease, is due, at least in part, to the inhibition of NO synthesis by macrophages by fungus-produced melanin.
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