ArticleInfection and immunity2006
Monoclonal antibody detection of CD46 clustering beneath Neisseria gonorrhoeae microcolonies.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Complement activity and autophagy are dysregulated in the lungs of patients with nonresolvable COVID-19 requiring lung transplantation.Respiratory research · 2025Article
- Neisseria gonorrhoeae subverts formin-dependent actin polymerization to colonize human macrophages.PLoS pathogens · 2021Article
- Neisseria gonorrhoeae evades autophagic killing by downregulating CD46-cyt1 and remodeling lysosomes.PLoS pathogens · 2019Article
- GP96 interacts with HHV-6 during viral entry and directs it for cellular degradation.PloS one · 2014Article
- Impact of calcium signaling during infection of Neisseria meningitidis to human brain microvascular endothelial cells.PloS one · 2014Article
- Type IV pilin proteins: versatile molecular modules.Microbiology and molecular biology reviews : MMBR · 2012Review
- Thyroid hormone enhances nitric oxide-mediated bacterial clearance and promotes survival after meningococcal infection.PloS one · 2012Article
- Chemotactic antiviral cytokines promote infectious apical entry of human adenovirus into polarized epithelial cells.Nature communications · 2011Article
- The dynamic processing of CD46 intracellular domains provides a molecular rheostat for T cell activation.PloS one · 2011Article
- Article
- Presenilin/gamma-secretase cleaves CD46 in response to Neisseria infection.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Influence of type IV pilus retraction on the architecture of the Neisseria gonorrhoeae-infected cell cortex.Microbiology (Reading, England) · 2009Article
- IFN-gamma amplifies NFkappaB-dependent Neisseria meningitidis invasion of epithelial cells via specific upregulation of CEA-related cell adhesion molecule 1.Cellular microbiology · 2007Article
- Microarray for serotyping of Bartonella species.BMC microbiology · 2007Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
CD46 (membrane cofactor protein), a complement-regulatory protein that participates in innate and acquired immunity, also serves as a receptor for viral and bacterial pathogens. CD46 isoforms terminate in one of two cytoplasmic tails, Cyt1 or Cyt2, which differ in signaling and trafficking properties. Dissecting the functions of the two cytoplasmic tails in these cellular processes has been hampered by the absence of specific reagents. Here we report the construction of Cyt1- and Cyt2-specific monoclonal antibodies (MAbs). These MAbs recognize unique epitopes within the tails and can be used for immunofluorescence microscopy, immunoblotting, and immunoprecipitation. Studies of Neisseria gonorrhoeae-infected cells with the CD46 tail MAbs demonstrate the differential recruitment of Cyt1 and Cyt2 to the cortical plaque.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.