ArticleInfection and immunity2006
Immunization enhances inflammation and tissue destruction in response to Porphyromonas gingivalis.
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Fermentation-Derived 6-Shogaol fromInternational journal of molecular sciences · 2026Article
- Luteolin's Potential in Managing Osteoporosis and Bone Metabolism Disorders: Preclinical Insights.Drug design, development and therapy · 2025Review
- TLR9 Signaling Is Required for theInternational journal of molecular sciences · 2023Article
- Computational Design of a Multi-Epitope Vaccine AgainstFrontiers in immunology · 2022Article
- Application of specialized pro-resolving mediators in periodontitis and peri-implantitis: a review.European journal of oral sciences · 2021Review
- Immunization with cell-free-generated vaccine protects from Porphyromonas gingivalis-induced alveolar bone loss.Journal of clinical periodontology · 2019Article
- Animal models for periodontal regeneration and peri-implant responses.Periodontology 2000 · 2015Review
- CD36/SR-B2-TLR2 Dependent Pathways Enhance Porphyromonas gingivalis Mediated Atherosclerosis in the Ldlr KO Mouse Model.PloS one · 2015Article
- Animal models to study host-bacteria interactions involved in periodontitis.Frontiers of oral biology · 2012Review
- Inflammation and uncoupling as mechanisms of periodontal bone loss.Journal of dental research · 2011Article
- Activation of the acquired immune response reduces coupled bone formation in response to a periodontal pathogen.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Gene expression in periodontal tissues following treatment.BMC medical genomics · 2008Article
- The use of rodent models to investigate host-bacteria interactions related to periodontal diseases.Journal of clinical periodontology · 2008Review
- Th1 immune response promotes severe bone resorption caused by Porphyromonas gingivalis.The American journal of pathology · 2007Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
It is well established that host-bacterium interactions play a critical role in the initiation and progression of periodontal diseases. By the use of inhibitors, it has been shown that mediators associated with the innate immune response significantly contribute to the disease process. Less is known regarding the role of the acquired immune response. To investigate mechanisms by which the acquired immune response to Porphyromonas gingivalis could affect connective tissue, we used a well-documented calvarial model to study host-bacterium interactions. Injection of P. gingivalis stimulated gamma interferon, interleukin 6, macrophage inflammatory protein 2, and monocyte chemoattractant protein 1 expression as determined by real-time PCR. Prior immunization against P. gingivalis significantly enhanced the mRNA levels of these cytokines and chemokines. Similarly, immunization significantly increased and prolonged the formation of a polymorphonuclear leukocyte and mononuclear cell infiltrate (P < 0.05). In addition, the area of connective tissue destruction, osteoclastogenesis, bone loss, mRNA expression of proapoptotic genes, and degree of fibroblast apoptosis were increased in immunized mice (P < 0.05). These results indicate that activation of the acquired immunity by P. gingivalis increases the inflammatory and destructive responses which occur in part through up-regulating the innate immune response and enhancing osteoclastogenesis and fibroblast apoptosis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.