ArticleInfection and immunity2006
Genetic resistance to Brucella abortus in the water buffalo (Bubalus bubalis).
Article in Infection and immunity, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 64 citations in OpenAlex.
- Urinary GC-MS metabolomics reveals pregnancy-associated metabolic reprogramming and biomarkers in buffaloes.BMC veterinary research · 2026Article
- Association Analysis ofAnimals : an open access journal from MDPI · 2025Article
- Seroprevalence and Risk Factors of Anaplasma marginale in Water Buffaloes in Nile Delta of Egypt.Acta parasitologica · 2025Article
- Nucleotide sequence variants, gene expression and serum profile of immune and antioxidant markers associated with brucellosis resistance/susceptibility in Shami goat.Irish veterinary journal · 2025Article
- Serological, cultural, and molecular analysis of Brucella from Buffalo milk in various regions of Iran.Veterinary research communications · 2024Article
- In Vitro, In Vivo and In Silico Assessment of the Antimicrobial and Immunomodulatory Effects of a Water Buffalo Cathelicidin (WBCATH) in Experimental Pulmonary Tuberculosis.Antibiotics (Basel, Switzerland) · 2022Article
- Identification of candidate genes associated with bacterial and viral infections in wild boars hunted in Tuscany (Italy).Scientific reports · 2022Article
- How Pathogens Feel and Overcome Magnesium Limitation When in Host Tissues.Trends in microbiology · 2021Review
- Genetic epidemiology of the Alpine ibex reservoir of persistent and virulent brucellosis outbreak.Scientific reports · 2020Article
- High Shedding Potential and Significant Individual Heterogeneity in Naturally-Infected Alpine ibex (Frontiers in microbiology · 2018Article
- Evaluation of the association of SLC11A1 gene polymorphism with incidence of paratuberculosis in goats.Journal of genetics · 2017Article
- Article
- Systematic Profiling of Short Tandem Repeats in the Cattle Genome.Genome biology and evolution · 2017Article
- Article
- Examining the role of components of Slc11a1 (Nramp1) in the susceptibility of New Zealand sea lions (Phocarctos hookeri) to disease.PloS one · 2015Article
- Diversity, Antimicrobial Action and Structure-Activity Relationship of Buffalo Cathelicidins.PloS one · 2015Article
- Retrospective and prospective perspectives on zoonotic brucellosis.Frontiers in microbiology · 2014Review
- A case-control study of risk factors for bovine brucellosis seropositivity in Peninsular Malaysia.PloS one · 2014Article
- Article
- Detection of antibodies against Brucella abortus, Leptospira spp., and Apicomplexa protozoa in water buffaloes in the Northeast of Argentina.Tropical animal health and production · 2013Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brucellosis is a costly disease of water buffaloes (Bubalus bubalis). Latent infections and prolonged incubation of the pathogen limit the efficacy of programs based on the eradication of infected animals. We exploited genetic selection for disease resistance as an approach to the control of water buffalo brucellosis. We tested 231 water buffalo cows for the presence of anti-Brucella abortus antibodies (by the agglutination and complement fixation tests) and the Nramp1 genotype (by PCR-denaturing gradient gel electrophoresis). When the 231 animals (58 cases and 173 controls) were divided into infected (seropositive) and noninfected (seronegative) groups and the Nramp1 genotypes were compared, the seropositive subjects were 52 out of 167 (31%) in the Nramp1A+ (Nramp1AA or Nramp1AB) group and 6 out of 64 (9.4%) in the Nramp1A- (Nramp1BB) group (odds ratio, 4.37; 95% confidence limits, 1.87 to 10.19; chi2, 11.65 for 1 degree of freedom). Monocytes from Nramp1BB subjects displayed significantly (P < 0.01) higher levels of Nramp1 mRNA than Nramp1AA subjects and also a significantly (P < 0.01) higher ability in controlling the intracellular replication of several Brucella species in vitro. Thus, selection for the Nramp1BB genotype can become a valuable tool for the control of water buffalo brucellosis in the areas where the disease is endemic.
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