ArticleAJNR. American journal of neuroradiology2006
Malignancy-associated vessel tortuosity: a computer-assisted, MR angiographic study of choroid plexus carcinoma in genetically engineered mice.
Article in AJNR. American journal of neuroradiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00630292 (Feasibility Study of Vessel Analysis for Noninvasive Diagnosis of Malignancy in Breast Tumors), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Feasibility Study of Vessel Analysis for Noninvasive Diagnosis of Malignancy in Breast Tumors
Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Predicting drug delivery efficiency into tumor tissues through molecular simulation of transport in complex vascular networks.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- Distinct Angiogenic Changes during Carcinogenesis Defined by Novel Label-Free Dark-Field Imaging in a Hamster Cheek Pouch Model.Cancer research · 2017Article
- First-in-Human Study of Acoustic Angiography in the Breast and Peripheral Vasculature.Ultrasound in medicine & biology · 2017Article
- Tumour angiogenesis as a chemo-mechanical surface instability.Scientific reports · 2016Article
- Quantification of Microvascular Tortuosity during Tumor Evolution Using Acoustic Angiography.Ultrasound in medicine & biology · 2015Article
- On the relationship between microbubble fragmentation, deflation and broadband superharmonic signal production.Ultrasound in medicine & biology · 2015Article
- In vivo X-ray digital subtraction and CT angiography of the murine cerebrovasculature using an intra-arterial route of contrast injection.AJNR. American journal of neuroradiology · 2012Article
- Vascular tortuosity: a mathematical modeling perspective.The journal of physiological sciences : JPS · 2012Article
- Comparison of digital subtraction angiography, micro-computed tomography angiography and magnetic resonance angiography in the assessment of the cerebrovascular system in live mice.Clinical neuroradiology · 2012Article
- Glioma morphology and tumor-induced vascular alterations revealed in seven rodent glioma models by in vivo magnetic resonance imaging and angiography.Journal of magnetic resonance imaging : JMRI · 2010Article
- Article
- Blood vessel morphologic changes depicted with MR angiography during treatment of brain metastases: a feasibility study.Radiology · 2007Article
- Internal pilots for a class of linear mixed models with Gaussian and compound symmetric data.Statistics in medicine · 2007Article
- Computer-assisted measurement of vessel shape from 3T magnetic resonance angiography of mouse brain.Methods (San Diego, Calif.) · 2007Article
- A review of micro- and macrovascular analyses in the assessment of tumor-associated vasculature as visualized by MR.NeuroImage · 2007Review
- Tumor therapeutic response and vessel tortuosity: preliminary report in metastatic breast cancer.Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
background and purposeThe ability to assess tumor malignancy and monitor treatment response noninvasively would be of value to both clinicians and animal investigators. This report describes the MR imaging characteristics of a genetically engineered mouse model of choroid plexus carcinoma (CPC) during tumor growth and progression to malignancy. We assess the ability of vessel tortuosity measurements, as calculated from high-resolution MR angiographic (MRA) images, to detect emerging CPC cancers.
methodsMR images of 9 healthy mice and of 20 CPC mice with precancerous choroid dysplasia or with cancer over a wide range of sizes were analyzed. Two vessel tortuosity measures and a measure of vessel attenuation (vessel count) were calculated from MRA images. Malignancy assessment was based upon a statistical analysis of vessel tortuosity, by using an equation derived from an earlier study of human brain tumor patients.
resultsChoroid dysplasia was correctly judged nonmalignant. On the basis of vessel count, neoangiogenesis could not be detected until cancers were full-blown and had reached a volume of approximately 80 mm3. Vessel tortuosity measurements, however, correctly identified emerging malignancy in lesions larger than 0.3 mm3.
conclusionTo the best of our knowledge, this report provides the first description of in vivo, MR imaging characteristics of genetically engineered CPC mice during the progression from dysplasia to cancer. Vessel tortuosity measurements offer promise of correctly defining even tiny tumors as malignant.
Indexed as
Identifiers
16552004PMC2504702W1952239748What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.