ArticleProceedings of the National Academy of Sciences of the United States of America2006
Optophysiology: depth-resolved probing of retinal physiology with functional ultrahigh-resolution optical coherence tomography.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers.
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Who cites it
114 citing papers in PubMed, 226 citations in OpenAlex.
- Spatio-temporal optical coherence imaging and tomography forJournal of biomedical optics · 2026Review
- Split-spectrum amplitude decorrelation optoretinography for functional imaging of mouse photoreceptors.Biomedical optics express · 2026Article
- Imaging of Tissue and Cell Dynamics: introduction to the feature issue.Biomedical optics express · 2026Article
- Recent Developments in Photoreceptor Optoretinography and Progress Toward Clinical Use.Translational vision science & technology · 2025Review
- On the physiological processes underlying optoretinography [Invited].Biomedical optics express · 2025Review
- Optoretinography with actively stabilized adaptive optics optical coherence tomography.Biomedical optics express · 2025Article
- Combined optical coherence tomography and electroretinography system for imaging neurovascular coupling in the human retina.Neurophotonics · 2025Article
- Insight into human photoreceptor function: Modeling optoretinographic responses to diverse stimuli.Science advances · 2025Article
- Evaluating the repeatability of the multifocal electroretinogram in the cone dominant 13-lined ground squirrel.Documenta ophthalmologica. Advances in ophthalmology · 2025Article
- Photopic flicker optoretinography captures the light-driven length modulation of photoreceptors during phototransduction.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Light-adapted flicker-optoretinography based on raster-scan optical coherence tomography towards clinical translation.Biomedical optics express · 2024Article
- Bichromatic tetraphasic full-field optical coherence microscopy.Journal of biomedical optics · 2024Article
- Parafoveal cone function in choroideremia assessed with adaptive optics optoretinography.Scientific reports · 2024Article
- The Impact of Photopigment Bleaching on the Human Rod Photoreceptor Subretinal Space Measured Via Optical Coherence Tomography.Investigative ophthalmology & visual science · 2024Article
- Intrinsic signal optoretinography of dark adaptation abnormality due to rod photoreceptor degeneration.Experimental biology and medicine (Maywood, N.J.) · 2024Article
- Intensity-based optoretinography reveals sub-clinical deficits in cone function in retinitis pigmentosa.Frontiers in ophthalmology · 2024Article
- Transducin-Deficient Rod Photoreceptors Evaluated With Optical Coherence Tomography and Oxygen Consumption Rate Energy Biomarkers.Investigative ophthalmology & visual science · 2022Article
- Retinal imaging using adaptive optics optical coherence tomography with fast and accurate real-time tracking.Biomedical optics express · 2022Article
- Coarse-scale optoretinography (CoORG) with extended field-of-view for normative characterization.Biomedical optics express · 2022Article
- Axonal architecture of the mouse inner retina revealed by second harmonic generation.PNAS nexus · 2022Article
54 more citing papers are in PubMed but not listed here.
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Noncontact, depth-resolved, optical probing of retinal response to visual stimulation with a <10-microm spatial resolution, achieved by using functional ultrahigh-resolution optical coherence tomography (fUHROCT), is demonstrated in isolated rabbit retinas. The method takes advantage of the fact that physiological changes in dark-adapted retinas caused by light stimulation can result in local variation of the tissue reflectivity. fUHROCT scans were acquired from isolated retinas synchronously with electrical recordings before, during, and after light stimulation. Pronounced stimulus-related changes in the retinal reflectivity profile were observed in the inner/outer segments of the photoreceptor layer and the plexiform layers. Control experiments (e.g., dark adaptation vs. light stimulation), pharmacological inhibition of photoreceptor function, and synaptic transmission to the inner retina confirmed that the origin of the observed optical changes is the altered physiological state of the retina evoked by the light stimulus. We have demonstrated that fUHROCT allows for simultaneous, noninvasive probing of both retinal morphology and function, which could significantly improve the early diagnosis of various ophthalmic pathologies and could lead to better understanding of pathogenesis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.