ArticleAnnals of the Royal College of Surgeons of England2006
Symptomatic presentation of early colorectal cancer.
Article in Annals of the Royal College of Surgeons of England, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Cancer diagnostic tools to aid decision-making in primary care: mixed-methods systematic reviews and cost-effectiveness analysis.Health technology assessment (Winchester, England) · 2020Pooled it
- Correlation between clinical features, medical history, and lifestyle factors with colorectal cancer stage.Future science OA · 2025Article
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- Predictors of Colon Cancer Screening Among the Saudi Population at Primary Healthcare Settings in Riyadh.Current oncology (Toronto, Ont.) · 2025Article
- Early Symptom Patterns by Tumor Laterality, Age at Onset, Stage, and Symptom-to-Treatment Initiation in Patients with Colorectal Cancer.Asian Pacific journal of cancer prevention : APJCP · 2024Article
- Delayed metastatic endometrial carcinoma mimicking primary colon adenocarcinoma: A surprise histopathological finding.Clinical case reports · 2024Article
- Engaging primary care physicians is critical in the screening and diagnosis of colorectal cancer at safety-net hospital systems.Surgery open science · 2024Article
- Application of nanotechnology in the early diagnosis and comprehensive treatment of gastrointestinal cancer.Journal of nanobiotechnology · 2022Review
- Impact of preoperative body mass index and weight loss on morbidity and mortality following colorectal cancer-a retrospective cohort study.International journal of colorectal disease · 2022Article
- Symptomatic Colorectal Cancer Is Associated With Stage IV Diagnosis in Two Disparate Populations.Cureus · 2022Article
- Awareness of colorectal cancer signs and symptoms: a national cross-sectional study from Palestine.BMC public health · 2022Article
- Colorectal Cancers in Low- and Middle-Income Countries-Demographic Pattern and Clinical Profile of 970 Patients Treated at a Tertiary Care Cancer Center in India.JCO global oncology · 2021Article
- Gender- and Race-Based Differences in Barriers and Facilitators to Early Detection of Colon Cancer.Journal of women's health (2002) · 2020Article
- Protocol for understanding acute sarcopenia: a cohort study to characterise changes in muscle quantity and physical function in older adults following hospitalisation.BMC geriatrics · 2020Article
- FOXC1 Regulation of miR-31-5p Confers Oxaliplatin Resistance by Targeting LATS2 in Colorectal Cancer.Cancers · 2019Article
- "-Omas" presenting as "-itis": acute inflammatory presentations of common gastrointestinal neoplasms.Emergency radiology · 2019Review
- Two case reports: Colorectal adenocarcinoma in children.Medicine · 2017Article
- The Role of MicroRNAs in the Chemopreventive Activity of Sulforaphane from Cruciferous Vegetables.Nutrients · 2017Review
- Factors associated with consultation behaviour for primary symptoms potentially indicating colorectal cancer: a cross-sectional study on response to symptoms.BMC gastroenterology · 2012Article
- How sharp can a screening tool be? A qualitative study of patients' experience of completing a bowel cancer screening questionnaire.Health expectations : an international journal of public participation in health care and health policy · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIt is believed that increased detection of earlier stage colorectal cancer can only be achieved by screening asymptomatic individuals. We describe a referral pathway for a symptomatic population which achieves a 30% Dukes' A detection rate. PATIENTS AND
methodsFrom October 1999, 4253 patients with distal colonic symptoms, referred by general practitioners, completed a patient consultation questionnaire (PCQ) linked to a computerised record. A weighted numerical score (WNS) was derived for each patient. Patients underwent flexible sigmoidoscopy, a diagnostic outcome was recorded and later Dukes' stage appended. Early and advanced colorectal cancers were separated and PCQ derived symptom profiles compared. Chi-square, Fisher exact, Student's t-test and logistic regression were used for statistical analysis.
resultsA total of 183 patients had cancer, 55 (30%) were Dukes' A early colorectal cancers, 112 were advanced colorectal cancers (Dukes' B-D) and 16 could not be staged. Early colorectal cancers had significant symptoms and comparable profile to advanced colorectal cancers. The tendency in advanced colorectal cancers was towards greater symptom prevalence for only a few primary and systemic symptoms, as reflected by a higher WNS of 75 (P = 0.001).
conclusionsEarly colorectal cancers do have significant symptoms which can easily be captured by a PCQ and objective scoring tool in the secondary care setting. Detection of these cancers has the potential to improve survival.
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