ArticleRespiratory research2006
Neonatal immune responses to TLR2 stimulation: influence of maternal atopy on Foxp3 and IL-10 expression.
Article in Respiratory research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 71 citations in OpenAlex.
- The difference in immune response and IL-12p35 methylation between newborns and adults.Journal of biomedical science · 2014Trial
- BORN TO WHEEZE OR LEARNED WHEN WE WERE YOUNG: MATERNAL AND ENVIRONMENTAL FACTORS INFLUENCE ATOPIC RISK.Transactions of the American Clinical and Climatological Association · 2023Article
- Associations Between Eczema and Attention Deficit Hyperactivity Disorder Symptoms in Children.Frontiers in pediatrics · 2022Article
- Atopic asthmatic immune phenotypes associated with airway microbiota and airway obstruction.PloS one · 2017Article
- Maternal allergic disease history affects childhood allergy development through impairment of neonatal regulatory T-cells.Respiratory research · 2016Article
- The Interaction Between Prenatal Exposure to Home Renovation and Reactive Oxygen Species Genes in Cord Blood IgE Response is Modified by Maternal Atopy.Allergy, asthma & immunology research · 2016Article
- Cohort profile: project viva.International journal of epidemiology · 2015Observational
- The neonatal susceptibility window for inhalant allergen sensitization in the atopically predisposed canine asthma model.Immunology · 2013Article
- Impaired function of regulatory T cells in cord blood of children of allergic mothers.Clinical and experimental immunology · 2012Article
- Profound deficit of IL10 at birth in children who develop childhood acute lymphoblastic leukemia.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2011Article
- Maternal signals for progeny prevention against allergy and asthma.Cellular and molecular life sciences : CMLS · 2011Review
- Toll-like receptors signaling contributes to immunopathogenesis of HBV infection.Gastroenterology research and practice · 2011Article
- Fetal epigenetic mechanisms and innate immunity in asthma.Current allergy and asthma reports · 2010Article
- Surfactant protein D-mediated decrease of allergen-induced inflammation is dependent upon CTLA4.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Parental characteristics, somatic fetal growth, and season of birth influence innate and adaptive cord blood cytokine responses.The Journal of allergy and clinical immunology · 2009Article
- Impaired Toll-like receptor 2 signalling in monocytes from 5-year-old allergic children.Clinical and experimental immunology · 2009Article
- Spontaneous preterm birth in African Americans is associated with infection and inflammatory response gene variants.American journal of obstetrics and gynecology · 2009Article
- Gene polymorphisms in Toll-like receptors, interleukin-10, and interleukin-10 receptor alpha and lymphoma risk.Genes and immunity · 2006Article
- Mode of delivery and cord blood cytokines: a birth cohort study.Clinical and molecular allergy : CMA · 2006Article
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundMaternal atopic background and stimulation of the adaptive immune system with allergen interact in the development of allergic disease. Stimulation of the innate immune system through microbial exposure, such as activation of the innate Toll-like-receptor 2 (TLR2), may reduce the development of allergy in childhood. However, little is known about the immunological effects of microbial stimulation on early immune responses and in association with maternal atopy.
methodsWe analyzed immune responses of cord blood mononuclear cells (CBMC) from 50 healthy neonates (31 non-atopic and 19 atopic mothers). Cells were stimulated with the TLR2 agonist peptidoglycan (Ppg) or the allergen house dust mite Dermatophagoides farinae (Derf1), and results compared to unstimulated cells. We analyzed lymphocyte proliferation and cytokine secretion of CBMC. In addition, we assessed gene expression associated with T regulatory cells including the transcription factor Foxp3, the glucocorticoid-induced TNF receptor (GITR), and the cytotoxic lymphocyte antigen 4 (CTLA4). Lymphocyte proliferation was measured by 3H-Thymidine uptake, cytokine concentrations determined by ELISA, mRNA expression of T cell markers by real-time RT-PCR.
resultsPpg stimulation induced primarily IL-10 cytokine production, in addition to IFN-gamma, IL-13 and TNF-alpha secretion. GITR was increased following Ppg stimulation (p = 0.07). Ppg-induced IL-10 production and induction of Foxp3 were higher in CBMC without, than with maternal atopy (p = 0.04, p = 0.049). IL-10 production was highly correlated with increased expression of Foxp3 (r = 0.53, p = 0.001), GITR (r = 0.47, p = 0.004) and CTLA4 (r = 0.49, p = 0.003), independent of maternal atopy.
conclusionTLR2 stimulation with Ppg induces IL-10 and genes associated with T regulatory cells, influenced by maternal atopy. Increased IL-10 and Foxp3 induction in CBMC of non-atopic compared to atopic mothers, may indicate an increased capacity to respond to microbial stimuli.
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