ArticleHistochemistry and cell biology2006
Sertoli cell function in albino rats treated with etoposide during prepubertal phase.
Article in Histochemistry and cell biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 29 citations in OpenAlex.
- Long-latency auditory evoked responses across species show increased amplitude during early life.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Non-alkylating agents-induced gonadotoxicity in pre-pubertal males: Insights on the clinical and pre-clinical front.Clinical and translational science · 2024Review
- Protective effects ofInternational journal of reproductive biomedicine · 2020Article
- Carnitine Diminishes Etoposide Toxic Action on Spermatogonial Self-renewal and Sperm Production in Adult Rats Treated in the Prepubertal Phase.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- Sertoli Cell Alterations in Peripubertal Varicocelized Rats: Evidence of Primary Damage on Spermatogenesis.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2020Article
- Exposure to Chemotherapy During Childhood or Adulthood and Consequences on Spermatogenesis and Male Fertility.International journal of molecular sciences · 2020Review
- How does chemotherapy treatment damage the prepubertal testis?Reproduction (Cambridge, England) · 2018Review
- Late morfofunctional alterations of the Sertoli cell caused by doxorubicin administered to prepubertal rats.Reproductive biology and endocrinology : RB&E · 2012Article
- Harmful effects of carbamazepine on the postnatal development of the rat ventral prostate.Reproductive biology and endocrinology : RB&E · 2012Article
- Anticancer chemotherapeutic agents and testicular dysfunction.Reproductive medicine and biology · 2011Review
- Recent progress in histochemistry.Histochemistry and cell biology · 2007Review
- The histochemistry and cell biology vade mecum: a review of 2005-2006.Histochemistry and cell biology · 2006Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sertoli cell plays a key role in spermatogenesis. Many studies refer that this cell is not harmed by the majority of anticancer treatments known to cause damage to the testis. However, in the previous study we observed that etoposide, an efficient chemotherapeutic drug, provokes an increase in numerical density of the Sertoli cells. This phenomenon suggests that this cell was harmed by etoposide. Thus, we decided to investigate a possible direct action of etoposide on Sertoli cells analyzing the function of this cell and relating it with the integrity and damage of the seminiferous epithelium. Prepubertal albino rats received 5 mg/kg of etoposide for eight consecutive days and were sacrificed in different ages. The control groups received 0.9% saline solution. The testes were fixed in Bouin's liquid for transferrin immunolabeling and testicular labeled tissue volume density measurement. Except for the younger rats, all the etoposide-treated rats showed diminution of transferrin immunolabeling in the seminiferous epithelium, and consequently, of total labeled testicular tissue volume density. We concluded that the diminution of transferrin labeling in the seminiferous epithelium was not associated with germ cell absence such as commonly reported. The results suggest etoposide impairs Sertoli cell function.
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