ArticleEvidence-based complementary and alternative medicine : eCAM2006
Analysis of the interactions of botanical extract combinations against the viability of prostate cancer cell lines.
Article in Evidence-based complementary and alternative medicine : eCAM, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed.
- Efficacy of rabdosia rubescens in the treatment of gingivitis.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2009Trial
- Molecular basis and mechanism of action ofChinese herbal medicines · 2023Review
- ANTIBACTERIAL EFFECTS OF SINGLE AND COMBINED CRUDE EXTRACTS OFAfrican journal of infectious diseases · 2022Article
- FangNet: Mining herb hidden knowledge from TCM clinical effective formulas using structure network algorithm.Computational and structural biotechnology journal · 2021Article
- Bioactive Potential of Extracts ofMolecules (Basel, Switzerland) · 2020Article
- Traditional Chinese Medicine in Depression Treatment: From Molecules to Systems.Frontiers in pharmacology · 2020Review
- Synergistic Effects of Chinese Herbal Medicine: A Comprehensive Review of Methodology and Current Research.Frontiers in pharmacology · 2016Review
- Advances in Synergistic Combinations of Chinese Herbal Medicine for the Treatment of Cancer.Current cancer drug targets · 2016Review
- Methodological problems with population cancer studies: The forgotten confounding factors.Surgical neurology international · 2015Article
- Saw palmetto ethanol extract inhibits adipocyte differentiation.Journal of natural medicines · 2013Article
- Impact of fixed-dose combination of germacrone, curdione, and furanodiene on breast cancer cell proliferation.Cell journal · 2013Article
- The potential anticancer activity of extracts derived from the roots ofMolecular and clinical oncology · 2013Article
- Ginseng (Panax quinquefolius) and Licorice (Glycyrrhiza uralensis) Root Extract Combinations Increase Hepatocarcinoma Cell (Hep-G2) Viability.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Analyzing Cytotoxic and Apoptogenic Properties of Scutellaria litwinowii Root Extract on Cancer Cell Lines.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- In Vitro Ultramorphological Assessment of Apoptosis on CEMss Induced by Linoleic Acid-Rich Fraction from Typhonium flagelliforme Tuber.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Cranberry and grape seed extracts inhibit the proliferative phenotype of oral squamous cell carcinomas.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Maternal baicalin treatment increases fetal lung surfactant phospholipids in rats.Evidence-based complementary and alternative medicine : eCAM · 2011Article
- Herb network construction and co-module analysis for uncovering the combination rule of traditional Chinese herbal formulae.BMC bioinformatics · 2010Article
- Genomic and in vivo evidence of synergy of a herbal extract compared to its most active ingredient: Rabdosia rubescens vs. oridonin.Experimental and therapeutic medicine · 2010Article
- Flavocoxid, a dual inhibitor of cyclooxygenase and 5-lipoxygenase, blunts pro-inflammatory phenotype activation in endotoxin-stimulated macrophages.British journal of pharmacology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Herbal medicines are often combinations of botanical extracts that are assumed to have additive or synergistic effects. The purpose of this investigation was to compare the effect of individual botanical extracts with combinations of extracts on prostate cell viability. We then modeled the interactions between botanical extracts in combination isobolographically. Scutellaria baicalensis, Rabdosia rubescens, Panax-pseudo ginseng, Dendranthema morifolium, Glycyrrhiza uralensis and Serenoa repens were collected, taxonomically identified and extracts prepared. Effects of the extracts on cell viability were quantitated in prostate cell lines using a luminescent ATP cell viability assay. Combinations of two botanical extracts of the four most active extracts were tested in the 22Rv1 cell line and their interactions assessed using isobolographic analysis. Each extract significantly inhibited the proliferation of prostate cell lines in a time- and dose-dependent manner except S. repens. The most active extracts, S. baicalensis, D. morifolium, G. uralensis and R. rubescens were tested as two-extract combinations. S. baicalensis and D. morifolium when combined were additive with a trend toward synergy, whereas D. morifolium and R. rubescens together were additive. The remaining two-extract combinations showed antagonism. The four extracts together were significantly more effective than the two-by-two combinations and the individual extracts alone. Combining the four herbal extracts significantly enhanced their activity in the cell lines tested compared with extracts alone. The less predictable nature of the two-way combinations suggests a need for careful characterization of the effects of each individual herb based on their intended use.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.