ArticleProceedings of the National Academy of Sciences of the United States of America2006
The cholinergic antagonist alpha-bungarotoxin also binds and blocks a subset of GABA receptors.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 46 citations in OpenAlex.
- Preclinical evidence of adenosine for early intervention in Bungarus multicinctus envenomation.Journal of advanced research · 2026Article
- Properties of Acute Activation and Inhibition of the β3 Homomeric GABAACS chemical neuroscience · 2025Article
- Pharmacological Screening of Venoms from Five BrazilianInternational journal of molecular sciences · 2022Article
- Article
- Novel Three-Finger Neurotoxins fromToxins · 2021Article
- Interaction of α9α10 Nicotinic Receptors With Peptides and Proteins From Animal Venoms.Frontiers in cellular neuroscience · 2021Article
- Immunoreactivity and neutralization study of Chinese Bungarus multicinctus antivenin and lab-prepared anti-bungarotoxin antisera towards purified bungarotoxins and snake venoms.PLoS neglected tropical diseases · 2020Article
- Bipolar Cell Type-Specific Expression and Conductance of Alpha-7 Nicotinic Acetylcholine Receptors in the Mouse Retina.Investigative ophthalmology & visual science · 2019Article
- Last decade update for three-finger toxins: Newly emerging structures and biological activities.World journal of biological chemistry · 2019Review
- Proteomic Investigation of Murine Neuronal α7-Nicotinic Acetylcholine Receptor Interacting Proteins.Journal of proteome research · 2018Article
- Evaluating Commercially Available Antibodies for Rat α7 Nicotinic Acetylcholine Receptors.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2017Article
- High-Affinity α-Conotoxin PnIA Analogs Designed on the Basis of the Protein Surface Topography Method.Scientific reports · 2016Article
- DISC1 Protein Regulates γ-Aminobutyric Acid, Type A (GABAA) Receptor Trafficking and Inhibitory Synaptic Transmission in Cortical Neurons.The Journal of biological chemistry · 2015Article
- Neurotoxins from snake venoms and α-conotoxin ImI inhibit functionally active ionotropic γ-aminobutyric acid (GABA) receptors.The Journal of biological chemistry · 2015Article
- Snake neurotoxin α-bungarotoxin is an antagonist at native GABA(A) receptors.Neuropharmacology · 2015Article
- Review
- MmTX1 and MmTX2 from coral snake venom potently modulate GABAA receptor activity.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- GABAA receptor membrane insertion rates are specified by their subunit composition.Molecular and cellular neurosciences · 2013Article
- Alpha7 nicotinic acetylcholine receptor is a target in pharmacology and toxicology.International journal of molecular sciences · 2012Review
- Traumatic brain injury elicits similar alterations in α7 nicotinic receptor density in two different experimental models.Neuromolecular medicine · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The polypeptide snake toxin alpha-bungarotoxin (BTX) has been used in hundreds of studies on the structure, function, and development of the neuromuscular junction because it binds tightly and specifically to the nicotinic acetylcholine receptors (nAChRs) at this synapse. We show here that BTX also binds to and blocks a subset of GABA(A) receptors (GABA(A)Rs) that contain the GABA(A)R beta3 subunit. These results introduce a previously unrecognized tool for analysis of GABA(A)Rs but may complicate interpretation of some studies on neuronal nAChRs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.