ArticleTissue engineering2006
Characterizing nanoscale topography of the aortic heart valve basement membrane for tissue engineering heart valve scaffold design.
Article in Tissue engineering, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 85 citations in OpenAlex.
- Microtubules and mechanosensing: key players in endothelial responses to mechanical stimuli.Cellular and molecular life sciences : CMLS · 2025Review
- The Effects of Biomimetic Surface Topography on Vascular Cells: Implications for Vascular Conduits.Advanced healthcare materials · 2024Review
- The influence of physical and spatial substrate characteristics on endothelial cells.Materials today. Bio · 2024Review
- Mimicking the Natural Basement Membrane for Advanced Tissue Engineering.Biomacromolecules · 2022Review
- Basement membrane properties and their recapitulation in organ-on-chip applications.Materials today. Bio · 2022Review
- Topography-induced large-scale antiparallel collective migration in vascular endothelium.Nature communications · 2022Article
- Developing biomaterials to mediate the spatial distribution of integrins.Biophysics reviews · 2021Review
- Aortic valve cell microenvironment: Considerations for developing a valve-on-chip.Biophysics reviews · 2021Review
- Regulation of Myogenic Differentiation by Topologically Microgrooved Surfaces for Skeletal Muscle Tissue Engineering.ACS omega · 2021Article
- Integration of substrate- and flow-derived stresses in endothelial cell mechanobiology.Communications biology · 2021Review
- Mineralized DNA-collagen complex-based biomaterials for bone tissue engineering.International journal of biological macromolecules · 2020Article
- Microphysiological Systems: Design, Fabrication, and Applications.ACS biomaterials science & engineering · 2020Article
- Engineering topography: Effects on corneal cell behavior and integration into corneal tissue engineering.Bioactive materials · 2019Review
- Bovine pericardial extracellular matrix niche modulates human aortic endothelial cell phenotype and function.Scientific reports · 2019Article
- Focal adhesion clustering drives endothelial cell morphology on patterned surfaces.Journal of the Royal Society, Interface · 2019Article
- Interactions of AMTN, ODAM and SCPPPQ1 proteins of a specialized basal lamina that attaches epithelial cells to tooth mineral.Scientific reports · 2017Article
- Combined effects of substrate topography and stiffness on endothelial cytokine and chemokine secretion.ACS applied materials & interfaces · 2015Article
- Nanoscale strategies: treatment for peripheral vascular disease and critical limb ischemia.ACS nano · 2015Review
- Nanotechnology in the Regeneration of Complex Tissues.Bone and tissue regeneration insights · 2014Article
- The influence of biomimetic topographical features and the extracellular matrix peptide RGD on human corneal epithelial contact guidance.Acta biomaterialia · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
A fully effective prosthetic heart valve has not yet been developed. A successful tissue-engineered valve prosthetic must contain a scaffold that fully supports valve endothelial cell function. Recently, topographic features of scaffolds have been shown to influence the behavior of a variety of cell types and should be considered in rational scaffold design and fabrication. The basement membrane of the aortic valve endothelium provides important parameters for tissue engineering scaffold design. This study presents a quantitative characterization of the topographic features of the native aortic valve endothelial basement membrane; topographical features were measured, and quantitative data were generated using scanning electron microscopy (SEM), atomic force microscopy (AFM), transmission electron microscopy (TEM), and light microscopy. Optimal conditions for basement membrane isolation were established. Histological, immunohistochemical, and TEM analyses following decellularization confirmed basement membrane integrity. SEM and AFM photomicrographs of isolated basement membrane were captured and quantitatively analyzed. The basement membrane of the aortic valve has a rich, felt-like, 3-D nanoscale topography, consisting of pores, fibers, and elevations. All features measured were in the sub-100 nm range. No statistical difference was found between the fibrosal and ventricular surfaces of the cusp. These data provide a rational starting point for the design of extracellular scaffolds with nanoscale topographic features that mimic those found in the native aortic heart valve basement membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.