ArticleJournal of medical systems2006
Computational approaches for predicting protein-protein interactions: a survey.
Article in Journal of medical systems, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Network reconstruction from infection cascades.Journal of the Royal Society, Interface · 2019Article
- The integration of weighted human gene association networks based on link prediction.BMC systems biology · 2017Article
- Integrating domain similarity to improve protein complexes identification in TAP-MS data.Proteome science · 2013Article
- Predicting protein-protein interface residues using local surface structural similarity.BMC bioinformatics · 2012Article
- Detection of protein complexes from affinity purification/mass spectrometry data.BMC systems biology · 2012Article
- Modularity analysis based on predicted protein-protein interactions provides new insights into pathogenicity and cellular process of Escherichia coli O157:H7.Theoretical biology & medical modelling · 2011Article
- Trees on networks: resolving statistical patterns of phylogenetic similarities among interacting proteins.BMC bioinformatics · 2010Article
- Triangle network motifs predict complexes by complementing high-error interactomes with structural information.BMC bioinformatics · 2009Article
- False positive reduction in protein-protein interaction predictions using gene ontology annotations.BMC bioinformatics · 2007Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Discovery of the protein interactions that take place within a cell can provide a starting point for understanding biological regulatory pathways. Global interaction patterns among proteins, for example, can suggest new drug targets and aid the design of new drugs by providing a clearer picture of the biological pathways in the neighborhoods of the drug targets. High-throughput experimental screens have been developed to detect protein-protein interactions, however, they show high rates of errors in terms of false positives and false negatives. Many computational approaches have been proposed to tackle the problem of protein-protein interaction prediction. They range from comparative genomics based methods to data integration based approaches. Challenging properties of protein-protein interaction data have to be addressed appropriately before a higher quality interaction map with better coverage can be achieved. This paper presents a survey of major works in computational prediction of protein-protein interactions, explaining their assumptions, main ideas, and limitations.
Indexed as
Identifiers
16548413What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.