ArticleOncogene2006
Human polyomavirus BKV transcriptionally activates DNA methyltransferase 1 through the pRb/E2F pathway.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 70 citations in OpenAlex.
- BK Polyomavirus in Pediatric Renal Transplantation-What We Know and What We Do Not.Biomedicines · 2024Review
- Histone deacetylase III interactions with BK polyomavirus large tumor antigen may affect protein stability.Virology journal · 2023Article
- NUP98 and RAE1 sustain progenitor function through HDAC-dependent chromatin targeting to escape from nucleolar localization.Communications biology · 2023Article
- Article
- Effect of the Large and Small T-Antigens of Human Polyomaviruses on Signaling Pathways.International journal of molecular sciences · 2019Review
- Activated MEK/ERK Pathway Drives Widespread and Coordinated Overexpression of UHRF1 and DNMT1 in Cancer cells.Scientific reports · 2019Article
- Microrna-217 modulates human skin fibroblast senescence by directly targeting DNA methyltransferase 1.Oncotarget · 2017Article
- Human Polyomaviruses: The Battle of Large and Small Tumor Antigens.Virology : research and treatment · 2017Review
- Mobile elements and viral integrations prompt considerations for bacterial DNA integration as a novel carcinogen.Cancer letters · 2014Review
- Influence of bacteria on epigenetic gene control.Cellular and molecular life sciences : CMLS · 2014Review
- HIV-1 Tat induces DNMT over-expression through microRNA dysregulation in HIV-related non Hodgkin lymphomas.Infectious agents and cancer · 2014Article
- Dysregulated transcriptional and post-translational control of DNA methyltransferases in cancer.Cell & bioscience · 2014Review
- Polyoma BK Virus: An Oncogenic Virus?Case reports in nephrology · 2013Article
- Zinc-induced Dnmt1 expression involves antagonism between MTF-1 and nuclear receptor SHP.Nucleic acids research · 2012Article
- Article
- Analysis of DNA methylation in human BK virus.Virus genes · 2011Article
- Epigenetic mechanisms in virus-induced tumorigenesis.Clinical epigenetics · 2011Article
- Nuclear receptor SHP inhibition of Dnmt1 expression via ERRγ.FEBS letters · 2011Article
- hNaa10p contributes to tumorigenesis by facilitating DNMT1-mediated tumor suppressor gene silencing.The Journal of clinical investigation · 2010Article
- Association of bladder adenocarcinoma and BK virus infection in a pancreatico-renal transplant recipient.NDT plus · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Many DNA tumor virus oncogenes are capable of activating and highjacking the host cell's DNA replication machinery for its own reproduction purposes through targeting and inactivation of the retinoblastoma pocket protein family. Pocket proteins function to regulate cell cycle progression and DNA synthesis through inhibitory interactions with the E2F transcription factors. The interaction of viral oncogenes with the pocket proteins is crucial for their transforming activity. We recently demonstrated that the DNA methyltransferase 1 (DNMT1) gene is an E2F target gene that is transcriptionally activated in cells lacking the retinoblastoma gene (Rb-/-). Overexpression of DNMT1 is implicated in tumor suppressor gene hypermethylation which is associated with tumorigenesis. Given that viral oncogenes potently stimulate E2F activity, we hypothesized that viral infection might activate DNMT1 and thereby promote transformation. Herein, we demonstrate that DNMT1 is strongly activated by the human polyomavirus BKV large T antigen (TAg) and adenovirus E1a. Viral oncogene mutants incapable of binding the pocket proteins are ineffective at activating DNMT1 compared to their wild-type counterparts. Additionally, mutation of the E2F sites within the DNMT1 promoters dramatically abrogates transcriptional activation. These data suggest that viral induction of DNMT1 through modulation of the pRB/E2F pathway may be involved in viral transformation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.