ArticleOncogene2006
p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability.
Article in Oncogene, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Comprehensive analysis indicated that NDE1 is a potential biomarker for pan-cancer and promotes bladder cancer progression.Cancer medicine · 2024Article
- MCRS1 is essential for epiblast development during early mouse embryogenesis.Reproduction (Cambridge, England) · 2020Article
- Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment.Molecular biology of the cell · 2019Article
- Cdk1 phosphorylation of the dynein adapter Nde1 controls cargo binding from G2 to anaphase.The Journal of cell biology · 2018Article
- Expression of MCRS1 and MCRS2 and their correlation with serum carcinoembryonic antigen in colorectal cancer.Experimental and therapeutic medicine · 2016Article
- MCRS1 associates with cytoplasmic dynein and mediates pericentrosomal material recruitment.Scientific reports · 2016Article
- The candidate oncogene (MCRS1) promotes the growth of human lung cancer cells via the miR-155-Rb1 pathway.Journal of experimental & clinical cancer research : CR · 2015Article
- Increased expression of the 58-kD microspherule protein (MSP58) is correlated with poor prognosis in glioma patients.Medical oncology (Northwood, London, England) · 2013Article
- NDE1 and NDEL1: twin neurodevelopmental proteins with similar 'nature' but different 'nurture'.Biomolecular concepts · 2013Review
- 58-kDa microspherule protein (MSP58) is novel Brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway.The Journal of biological chemistry · 2012Article
- Ndel1-derived peptides modulate bidirectional transport of injected beads in the squid giant axon.Biology open · 2012Article
- K-fibre minus ends are stabilized by a RanGTP-dependent mechanism essential for functional spindle assembly.Nature cell biology · 2011Article
- A new cap for kinetochore fibre minus ends.Nature cell biology · 2011Article
- PKA phosphorylation of NDE1 is DISC1/PDE4 dependent and modulates its interaction with LIS1 and NDEL1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Developmental expression patterns of candidate cofactors for vertebrate six family transcription factors.Developmental dynamics : an official publication of the American Association of Anatomists · 2010Article
- Drosophila MCRS2 associates with RNA polymerase II complexes to regulate transcription.Molecular and cellular biology · 2010Article
- Ndel1 palmitoylation: a new mean to regulate cytoplasmic dynein activity.The EMBO journal · 2010Article
- Article
- RNAi-mediated inhibition of MSP58 decreases tumour growth, migration and invasion in a human glioma cell line.Journal of cellular and molecular medicineArticle
- The molecular characteristics and functional roles of microspherule protein 1 (MCRS1) in gene expression, cell proliferation, and organismic development.Cell cycle (Georgetown, Tex.)Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The centrosome, an organelle that functions as the major microtubule-organizing center, plays an essential role in the formation of the mitotic spindle and guiding accurate chromosome segregation. Centrosome aberrations are frequently associated with various forms of human cancers and it is thought that defects in this organelle contribute to genomic instability and malignant transformation. We recently identified and characterized a centrosome-localized protein complex that is comprised of Su48 and Nde1. Disruption of the normal function of these proteins leads to abnormal cell division. To extend our understanding of how this protein complex operates, we sought to identify Nde1-interacting molecules by the yeast two-hybrid screening method. Here, we demonstrate that both Nde1 and Su48 can associate with p78/MCRS1, a protein implicated in cancer development. We found that, whereas the majority of p78 localizes to the nucleus as reported in earlier studies, a fraction of the p78 protein can be detected in the centrosome. Moreover, we determined that a region containing the forkhead-associated domain of p78 is involved in association with Nde1 and Su48, as well as in centrosomal localization. We also provide evidence that the association between p78 and Nde1 is regulated by phosphorylation on Nde1. Furthermore, abrogation of the endogenous p78 function by small interfering RNA knockdown causes cell death and a modest delay in mitosis. These results indicate that a subset of the p78 proteins comprises a component of the centrosome and that p78 is essential for cell viability.
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