ArticleLearning & memory (Cold Spring Harbor, N.Y.)
Fos and Egr1 expression in the rat brain in response to olfactory cue after taste-potentiated odor aversion retrieval.
Article in Learning & memory (Cold Spring Harbor, N.Y.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Common brain activations for painful and non-painful aversive stimuli.BMC neuroscience · 2012Pooled it
- Contribution of Rat Insular Cortex to Stimulus-Guided Action.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
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- Mu opioid receptors in the medial preoptic area govern social play behavior in adolescent male rats.Genes, brain, and behavior · 2020Article
- The Origins and Organization of Vertebrate Pavlovian Conditioning.Cold Spring Harbor perspectives in biology · 2015Review
- The brain's response to an essential amino acid-deficient diet and the circuitous route to a better meal.Molecular neurobiology · 2012Review
- Involvement of newborn neurons in olfactory associative learning? The operant or non-operant component of the task makes all the difference.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Identifying a network of brain regions involved in aversion-related processing: a cross-species translational investigation.Frontiers in integrative neuroscience · 2011Article
- Associatively learned representations of taste outcomes activate taste-encoding neural ensembles in gustatory cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- The way an odor is experienced during aversive conditioning determines the extent of the network recruited during retrieval: a multisite electrophysiological study in rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
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Authors and funding
3 authors at 2 institutions in 1 country.
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Abstract
When an odor is paired with a delayed illness, rats acquire a relatively weak odor aversion. In contrast, rats develop a strong aversion to an olfactory cue paired with delayed illness if it is presented simultaneously with a gustatory cue. Such a conditioning effect has been referred to as taste-potentiated odor aversion learning (TPOA). TPOA is an interesting model for studying neural mechanisms of plasticity because of its robustness and rapid acquisition. However, the neural substrate involved in TPOA retrieval has not been well characterized. To address this question, we used immunocytochemical detection of inducible transcription factors encoded by the immediate-early genes Fos and Egr1. Thirsty male rats were conditioned to TPOA learning, and they were submitted to retrieval in the presence of the learned odor 3 d later. Significant increases in both Fos and Egr1 expressions were observed in basolateral amygdala, insular cortex, and hippocampus in aversive rats in comparison with the all the control groups. The pattern of neuronal activity seemed unlikely to be related to the sole LiCl injection. Lastly, opposite patterns of Fos and Egr1 were noted in the entorhinal cortex and the central nucleus of amygdala, suggesting a differential involvement of these markers in retrieval of TPOA.
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