ArticleGenetics2006
Increase of the spontaneous mutation rate in a long-term experiment with Drosophila melanogaster.
Article in Genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 35 citations in OpenAlex.
- Evolution of the rate, molecular spectrum, and fitness effects of mutation under minimal selection in Caenorhabditis elegans.Genetics · 2026Article
- Evolution of the rate, molecular spectrum, and fitness effects of mutation under minimal selection inbioRxiv : the preprint server for biology · 2026Article
- The rate and molecular spectrum of mutation are selectively maintained in yeast.Nature communications · 2021Article
- Review
- Accelerated inbreeding depression suggests synergistic epistasis for deleterious mutations in Drosophila melanogaster.Heredity · 2019Article
- Eukaryote hybrid genomes.PLoS genetics · 2019Article
- Evolution of the Mutational Process under Relaxed Selection in Caenorhabditis elegans.Molecular biology and evolution · 2019Article
- Hierarchical Assessment of Mutation Properties inG3 (Bethesda, Md.) · 2018Article
- Rates and Patterns of Mutation in Tandem Repetitive DNA in Six Independent Lineages of Chlamydomonas reinhardtii.Genome biology and evolution · 2018Article
- Accelerating Mutational Load Is Not Due to Synergistic Epistasis or Mutator Alleles in Mutation Accumulation Lines of Yeast.Genetics · 2016Article
- The evolution of mutation rate in an antagonistic coevolutionary model with maternal transmission of parasites.Proceedings. Biological sciences · 2013Article
- Genomic background and generation time influence deleterious mutation rates in Daphnia.Genetics · 2013Article
- The effect of sexual harassment on lethal mutation rate in female Drosophila melanogaster.Proceedings. Biological sciences · 2013Article
- Invariance (?) of mutational parameters for relative fitness over 400 generations of mutation accumulation in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2012Article
- Evidence for elevated mutation rates in low-quality genotypes.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Measurements of spontaneous rates of mutations in the recent past and the near future.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Article
- Analysis and implications of mutational variation.Genetica · 2009Review
- Article
- Does mutation rate depend on itself.PLoS biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a previous experiment, the effect of 255 generations of mutation accumulation (MA) on the second chromosome viability of Drosophila melanogaster was studied using 200 full-sib MA1 lines and a large C1 control, both derived from a genetically homogeneous base population. At generation 265, one of those MA1 lines was expanded to start 150 new full-sib MA2 lines and a new C2 large control. After 46 generations, the rate of decline in mean viability in MA2 was approximately 2.5 times that estimated in MA1, while the average degree of dominance of mutations was small and nonsignificant by generation 40 and moderate by generation 80. In parallel, the inbreeding depression rate for viability and the amount of additive variance for two bristle traits in C2 were 2-3 times larger than those in C1. The results are consistent with a mutation rate in the line from which MA2 and C2 were derived about 2.5 times larger than that in MA1. The mean viability of C2 remained roughly similar to that of C1, but the rate of MA2 line extinction increased progressively, leading to mutational collapse, which can be ascribed to accelerated mutation and/or synergy after important deleterious accumulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.