ArticleArchives of disease in childhood2006
Symptomatic toxoplasma infection due to congenital and postnatally acquired infection.
Article in Archives of disease in childhood, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 63 citations in OpenAlex.
- Exploring the potential of Toxoplasma gondii in drug development and as a delivery system.Experimental & molecular medicine · 2024Review
- Reduced neural progenitor cell count and cortical neurogenesis in guinea pigs congenitally infected with Toxoplasma gondii.Communications biology · 2023Article
- Establishment and validation of a guinea pig model for human congenital toxoplasmosis.Parasites & vectors · 2021Article
- Prevention and mitigation of congenital toxoplasmosis. Economic costs and benefits in diverse settings.Food and waterborne parasitology · 2019Review
- Congenital toxoplasmosis in Austria: Prenatal screening for prevention is cost-saving.PLoS neglected tropical diseases · 2017Article
- Sero-epidemiology and risk factors for Toxoplasma gondii among pregnant women in Arab and African countries.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2016Article
- Eye pathologies in neonates.International journal of ophthalmology · 2016Review
- Immune profiling of pregnant Toxoplasma-infected US and Colombia patients reveals surprising impacts of infection on peripheral blood cytokines.The Journal of infectious diseases · 2014Article
- Evaluation of a new protocol for retrospective diagnosis of congenital toxoplasmosis by use of Guthrie cards.Journal of clinical microbiology · 2014Article
- A dedicated surveillance network for congenital toxoplasmosis in Greece, 2006-2009: assessment of the results.BMC public health · 2012Article
- A morphological approach to the diagnosis of protozoal infections of the central nervous system.Pathology research international · 2011Article
- Recovery of anti-Toxoplasma gondii immunoglobulin M in stored guthrie card blood spots.Journal of clinical microbiology · 2009Article
- Survey of European programmes for the epidemiological surveillance of congenital toxoplasmosis.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2008Review
- Newborn screening for congenital toxoplasmosis: feasible, but benefits are not established.Archives of disease in childhood · 2006Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo determine the incidence and severity of symptomatic toxoplasma infection presenting during childhood due to congenital or postnatally acquired infection.
methodsBetween 2002 and 2004, newly diagnosed children (<16 years) with signs or symptoms of congenital or ocular toxoplasmosis were reported by clinicians to the British Paediatric and Ophthalmic Surveillance Units or by toxoplasma referral laboratories. Confirmed cases were estimated to have a greater than 50% probability of congenital and/or ocular toxoplasmosis, based on clinical and serological findings.
resultsThirty eight children had confirmed toxoplasma infection. Twenty two (58%) were classified with congenital infection (cumulative incidence for England and Wales 1.62[corrected]/100,000 live births; 95% CI 0.85[corrected] to 2.83[corrected]), of whom 2 (9%) were stillborn, 7 (32%) live births had intracranial abnormalities and/or developmental delay (5 of whom had retinochoroiditis), and 10 (45%) had retinochoroiditis with no other abnormalities reported. A further 16 (42%) children were classified as infected after birth; all had retinochoroiditis.
conclusionsThe low burden of symptomatic congenital toxoplasmosis combined with the lack of evidence of an effective treatment support current policy not to offer prenatal or neonatal screening for toxoplasma infection. Primary prevention strategies need to address acquisition of infection in childhood which accounts for half the ocular disease due to toxoplasma infection in children in the UK and Ireland.
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