ArticleJournal of bacteriology2006
Control of formation and cellular detachment from Shewanella oneidensis MR-1 biofilms by cyclic di-GMP.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
115 citing papers in PubMed, 227 citations in OpenAlex.
- Shewanella oneidensis: Biotechnological Application of Metal-Reducing Bacteria.Advances in biochemical engineering/biotechnology · 2025Review
- Comparative analysis of the influence of BpfA and BpfG on biofilm development and current density in Shewanella oneidensis under oxic, fumarate- and anode-respiring conditions.Scientific reports · 2024Article
- BpfD Is a c-di-GMP Effector Protein Playing a Key Role for Pellicle Biosynthesis inInternational journal of molecular sciences · 2024Article
- Molecular Mechanisms of Biofilm Formation on Orthopaedic Implants: Review of the Literature.Maedica · 2024Article
- Multiple biological characteristics and functions of intestinal biofilm extracellular polymers: friend or foe?Frontiers in microbiology · 2024Review
- A bibliography study of Shewanella oneidensis biofilm.FEMS microbiology ecology · 2023Article
- Systematic Full-Cycle Engineering Microbial Biofilms to Boost Electricity Production inResearch (Washington, D.C.) · 2023Article
- Polarity of c-di-GMP synthesis and degradation.microLife · 2023Review
- The Alginate and Motility Regulator AmrZ is Essential for the Regulation of the Dispersion Response bymSphere · 2022Article
- Review
- GGDEF domain as spatial on-switch for a phosphodiesterase by interaction with landmark protein HubP.NPJ biofilms and microbiomes · 2022Article
- Article
- Surface Texturing and Combinatorial Approaches to Improve Biocompatibility of Implanted Biomaterials.Frontiers in physics · 2022Article
- OhrR is a central transcriptional regulator of virulence in Dickeya zeae.Molecular plant pathology · 2022Article
- Microbial fuel cells and their electrified biofilms.Biofilm · 2021Article
- Role of c-di-GMP in improving stress resistance of alginate-chitosan microencapsulated Bacillus subtilis cells in simulated digestive fluids.Biotechnology letters · 2021Article
- Reduction of alternative electron acceptors drives biofilm formation in Shewanella algae.NPJ biofilms and microbiomes · 2021Article
- Regulation of c-di-GMP in Biofilm Formation of Klebsiella pneumoniae in Response to Antibiotics and Probiotic Supernatant in a Chemostat System.Current microbiology · 2021Article
- The Stand-Alone PilZ-Domain Protein MotL Specifically Regulates the Activity of the Secondary Lateral Flagellar System inFrontiers in microbiology · 2021Article
- Identification of a Putative Sensor Protein Involved in Regulation of Vesicle Production by a Hypervesiculating Bacterium,Frontiers in microbiology · 2021Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stability and resilience against environmental perturbations are critical properties of medical and environmental biofilms and pose important targets for their control. Biofilm stability is determined by two mutually exclusive processes: attachment of cells to and detachment from the biofilm matrix. Using Shewanella oneidensis MR-1, an environmentally versatile, Fe(III) and Mn(IV) mineral-reducing microorganism, we identified mxdABCD as a new set of genes essential for formation of a three-dimensional biofilm. Molecular analysis revealed that mxdA encodes a cyclic bis(3',5')guanylic acid (cyclic di-GMP)-forming enzyme with an unusual GGDEF motif, i.e., NVDEF, which is essential for its function. mxdB encodes a putative membrane-associated glycosyl transferase. Both genes are essential for matrix attachment. The attachment-deficient phenotype of a DeltamxdA mutant was rescued by ectopic expression of VCA0956, encoding another diguanylate cyclase. Interestingly, a rapid cellular detachment from the biofilm occurred upon induction of yhjH, a gene encoding an enzyme that has been shown to have phosphodiesterase activity. In this way, it was possible to bypass the previously identified sudden depletion of molecular oxygen as an environmental trigger to induce biofilm dissolution. We propose a model for c-di-GMP as a key intracellular regulator for controlling biofilm stability by shifting the state of a biofilm cell between attachment and detachment in a concentration-dependent manner.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.