ArticleJournal of bacteriology2006
Chromosome evolution in the Thermotogales: large-scale inversions and strain diversification of CRISPR sequences.
Article in Journal of bacteriology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 64 citations in OpenAlex.
- Pervasive genome structure heterogeneity iniScience · 2026Article
- Prospective Advances in Genome Editing Investigation.Advances in experimental medicine and biology · 2023Article
- Article
- New Insights into the Therapeutic Applications of CRISPR/Cas9 Genome Editing in Breast Cancer.Genes · 2021Review
- Genome editing: A perspective on the application of CRISPR/Cas9 to study human diseases (Review).International journal of molecular medicine · 2019Review
- Gene inversion potentiates bacterial evolvability and virulence.Nature communications · 2018Article
- Complete genome sequence ofStandards in genomic sciences · 2017Article
- CRISPR-Cas: biology, mechanisms and relevance.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Review
- Functional analysis of the first complete genome sequence of a multidrug resistant sequence type 2Microbial genomics · 2016Article
- CRISPRDetect: A flexible algorithm to define CRISPR arrays.BMC genomics · 2016Article
- Detecting Horizontal Gene Transfer between Closely Related Taxa.PLoS computational biology · 2015Article
- Knowledge-based discovery for designing CRISPR-CAS systems against invading mobilomes in thermophiles.Systems and synthetic biology · 2015Article
- CRISPR-Cas systems: beyond adaptive immunity.Nature reviews. Microbiology · 2014Review
- A role for [Fe4S4] clusters in tRNA recognition--a theoretical study.Nucleic acids research · 2014Article
- Bacterial genome instability.Microbiology and molecular biology reviews : MMBR · 2014Review
- Virus-host and CRISPR dynamics in Archaea-dominated hypersaline Lake Tyrrell, Victoria, Australia.Archaea (Vancouver, B.C.) · 2013Article
- Characterization of the CRISPR/Cas subtype I-A system of the hyperthermophilic crenarchaeon Thermoproteus tenax.Journal of bacteriology · 2012Article
- A dual function of the CRISPR-Cas system in bacterial antivirus immunity and DNA repair.Molecular microbiology · 2011Article
- The genus Thermotoga: recent developments.Environmental technology · 2010Article
- The CRISPR system: small RNA-guided defense in bacteria and archaea.Molecular cell · 2010Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the present study, the chromosomes of two members of the Thermotogales were compared. A whole-genome alignment of Thermotoga maritima MSB8 and Thermotoga neapolitana NS-E has revealed numerous large-scale DNA rearrangements, most of which are associated with CRISPR DNA repeats and/or tRNA genes. These DNA rearrangements do not include the putative origin of DNA replication but move within the same replichore, i.e., the same replicating half of the chromosome (delimited by the replication origin and terminus). Based on cumulative GC skew analysis, both the T. maritima and T. neapolitana lineages contain one or two major inverted DNA segments. Also, based on PCR amplification and sequence analysis of the DNA joints that are associated with the major rearrangements, the overall chromosome architecture was found to be conserved at most DNA joints for other strains of T. neapolitana. Taken together, the results from this analysis suggest that the observed chromosomal rearrangements in the Thermotogales likely occurred by successive inversions after their divergence from a common ancestor and before strain diversification. Finally, sequence analysis shows that size polymorphisms in the DNA joints associated with CRISPRs can be explained by expansion and possibly contraction of the DNA repeat and spacer unit, providing a tool for discerning the relatedness of strains from different geographic locations.
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