ArticleBiochemical and biophysical research communications2006
NMDA receptor activation induces translocation and activation of Rac in mouse hippocampal area CA1.
Article in Biochemical and biophysical research communications, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Neuronal Actin Remodeling and Its Role in Higher Nervous Activity.International journal of molecular sciences · 2025Review
- Review
- Roles of palmitoylation in structural long-term synaptic plasticity.Molecular brain · 2021Review
- Role of actin cytoskeleton in the organization and function of ionotropic glutamate receptors.Current research in structural biology · 2021Review
- Stress-Sensitive Protein Rac1 and Its Involvement in Neurodevelopmental Disorders.Neural plasticity · 2020Review
- Voluntary exercise rescues sevoflurane-induced memory impairment in aged male mice.Experimental brain research · 2016Article
- The calcium sensor Copine-6 regulates spine structural plasticity and learning and memory.Nature communications · 2016Article
- The potential role of rho GTPases in Alzheimer's disease pathogenesis.Molecular neurobiology · 2014Review
- Protein prenylation and synaptic plasticity: implications for Alzheimer's disease.Molecular neurobiology · 2014Review
- Differential role of Rac in the basolateral amygdala and cornu ammonis 1 in the reconsolidation of auditory and contextual Pavlovian fear memory in rats.Psychopharmacology · 2014Article
- MAP1B-dependent Rac activation is required for AMPA receptor endocytosis during long-term depression.The EMBO journal · 2013Article
- Region-specific role of Rac in nucleus accumbens core and basolateral amygdala in consolidation and reconsolidation of cocaine-associated cue memory in rats.Psychopharmacology · 2013Article
- Neuronal Rac1 is required for learning-evoked neurogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Characteristic features of stem cells in glioblastomas: from cellular biology to genetics.Brain pathology (Zurich, Switzerland) · 2012Review
- Modulation of dendritic spines and synaptic function by Rac1: a possible link to Fragile X syndrome pathology.Brain research · 2011Article
- The roles of the actin cytoskeleton in fear memory formation.Frontiers in behavioral neuroscience · 2011Article
- Isoprenoids, small GTPases and Alzheimer's disease.Biochimica et biophysica acta · 2010Review
- Neurochemical, behavioral and architectural changes after chronic inactivation of NMDA receptors in mice.Neuroscience letters · 2010Article
- NMDA receptor activation increases free radical production through nitric oxide and NOX2.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Pharmacological inactivation of the small GTPase Rac1 impairs long-term plasticity in the mouse hippocampus.NeuropharmacologyArticle
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Neuronal development requires several discrete morphological steps that are believed to involve the small GTPase Rac. For example, neural activity, through NMDA receptors and/or AMPA receptors, activates Rac leading to elaboration of dendritic arbors. In the current study, we have conducted studies which indicate that Rac might be an important molecule involved in morphological plasticity in the adult mouse. We demonstrate that Rac is expressed at synapses in the adult mouse hippocampus. We also demonstrate that treatment of hippocampal slices with NMDA induces membrane translocation and activation of Rac in area CA1. Interestingly, we also find that there is an increase in Rac that is associated with NMDA receptor complexes following NMDA receptor activation. Taken together, our data are consistent with the idea that Rac could be participating in NMDA receptor-dependent changes in morphology that occur during synaptic plasticity and memory formation in the adult mouse hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.