ArticleProceedings of the National Academy of Sciences of the United States of America1991
Retinoic acid affects the expression of nuclear retinoic acid receptors in tissues of retinol-deficient rats.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 127 citations in OpenAlex.
- Vitamin A for preventing acute lower respiratory tract infections in children up to seven years of age.The Cochrane database of systematic reviews · 2008Pooled it
- Hepatocyte Nuclear Factor 4α (HNF4α) Plays a Controlling Role in Expression of the Retinoic Acid Receptor β (International journal of molecular sciences · 2023Article
- Retinoic acid promotes fibrinolysis and may regulate polyp formation.The Journal of allergy and clinical immunology · 2022Article
- Combining phenotypic profiling and targeted RNA-Seq reveals linkages between transcriptional perturbations and chemical effects on cell morphology: Retinoic acid as an example.Toxicology and applied pharmacology · 2022Article
- Enhancement of tumor suppressor RAR-β protein expression by cationic liposomal-ATRA treatment in benzo(a)pyrene-induced lung cancer mice model.Naunyn-Schmiedeberg's archives of pharmacology · 2019Article
- Impact of Triple Combinations of Retinoic Acid, Mold Spores and Citral on the F344 Rat Lung Tissue Pathology.Biomedical sciences instrumentation · 2016Article
- The Negative Impact of Combining Retinoic Acid (ATRA) and Mold Spores on F344 Rat Lung and Improvement of Tissue Pathology by Citral.Biomedical sciences instrumentation · 2015Article
- Health Impact of Retinoic Acid (ATRA) on Ovalbumin-Sensitized F344 Rat Lung and Improvement of Tissue Pathology by Citral.Biomedical sciences instrumentation · 2015Article
- Biological functional annotation of retinoic acid alpha and beta in mouse liver based on genome-wide binding.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- Impact of paired combinations of retinoic Acid (atra) and ovalbumin on f344 rat lung tissues and improvement of related pathology by citral.Biomedical sciences instrumentation · 2014Article
- Experimental induction of lung damage in the f344 rat upon exposure to citral, retinoic Acid (atra), ovalbumin and mold spores.Biomedical sciences instrumentation · 2014Article
- A novel bidirectional interaction between endothelin-3 and retinoic acid in rat enteric nervous system precursors.PloS one · 2013Article
- Impact of supra-physiologic retinoids on ovalbumin-sensitized f344 lung tissue and reversal of related pathology by citral - biomed 2011.Biomedical sciences instrumentation · 2011Article
- Mechanisms and significance of nuclear receptor auto- and cross-regulation.General and comparative endocrinology · 2011Review
- Retinoic acid administration and vitamin A status modulate retinoid X receptor alpha and retinoic acid receptor alpha levels in mouse brown adipose tissue.Molecular and cellular biochemistry · 2004Article
- Hyperglycaemia potentiates the teratogenicity of retinoic acid in diabetic pregnancy in mice.Diabetologia · 2004Article
- Retinoic acid receptor alpha and retinoid X receptor specific agonists reduce renal injury in established chronic glomerulonephritis of the rat.Journal of molecular medicine (Berlin, Germany) · 2004Article
- Alterations in binding characteristics of peripheral benzodiazepine receptors in testes by vitamin A deficiency in guinea pigs.Molecular and cellular biochemistry · 2000Article
- Immunochemical and in situ hybridization analyses of retinoic acid receptor alpha, beta, and gamma in murine Harderian and submandibular glands.Histochemistry and cell biology · 1996Article
- Vitamin A deficiency and the expression of retinoic acid receptors during early cardiogenesis in quail embryo.Roux's archives of developmental biology : the official organ of the EDBO · 1996Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The multitude of biological effects of the vitamin A metabolite, retinoic acid, are mediated by nuclear retinoic acid receptors (RARs), which are members of the steroid/thyroid hormone receptor superfamily. RAR-alpha, -beta, and -gamma are encoded by three genes from which multiple isoforms can be generated. Recent studies suggest that the expression of at least some RAR isoforms can be regulated by retinoic acid in certain cell lines. Here we examined regulation of RAR expression in the adult animal. RARs were analyzed by Northern blots from lung, liver, and testes of retinol-deficient rats. Retinol deficiency caused a 65-70% decrease in the mRNA levels of lung and liver RAR-beta, whereas no change was observed in RAR-alpha and -gamma mRNA levels in these organs. In the testes of retinol-deficient animals, two transcripts, RAR-alpha 1 (3.7 kb) and RAR-alpha 2 (2.8 kb), were detected as compared with one RAR-alpha 1 (3.7 kb) transcript in retinol-sufficient testes. When retinol-deficient rats were orally administered 1 dose of retinoic acid (100 micrograms per rat), lung RAR-beta mRNA levels started to increase after 1 hr and reached a 16-fold higher level after 4 hr; after 4 hr these retinoic acid-fed rats also showed a 7-fold increase in liver RAR-beta mRNA levels as compared with levels in the retinol-deficient rats. In contrast, liver, lung, and testes RAR-alpha transcripts remained either unchanged or showed only a slight increase in response to retinoic acid. RAR-gamma was constitutively expressed in lung, and its mRNA levels were induced 2-fold by retinoic acid. These results show tissue diversity in the rapid induction of RAR-beta and RAR-gamma by retinoic acid in the adult animal and suggest distinct roles for the various receptor isoforms in the control of the retinoid response.
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