ArticleGenetical research2006
Bayesian analyses of multiple epistatic QTL models for body weight and body composition in mice.
Article in Genetical research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 42 citations in OpenAlex.
- Genetic Bases of Complex Traits: From Quantitative Trait Loci to Prediction.Methods in molecular biology (Clifton, N.J.) · 2022Article
- QTL Mapping on a Background of Variance Heterogeneity.G3 (Bethesda, Md.) · 2018Article
- Bayesian analysis of additive epistasis arising from new mutations in mice.Genetics research · 2014Article
- A pronounced evolutionary shift of the pseudoautosomal region boundary in house mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2012Article
- Article
- Extensive epistasis for olfactory behaviour, sleep and waking activity in Drosophila melanogaster.Genetics research · 2012Article
- Dissection of QTL effects for root traits using a chromosome arm-specific mapping population in bread wheat.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2011Article
- Article
- Sex-, diet-, and cancer-dependent epistatic effects on complex traits in mice.Frontiers in genetics · 2011Article
- Fine-mapping of obesity-related quantitative trait loci in an F9/10 advanced intercross line.Obesity (Silver Spring, Md.) · 2010Article
- Mapping main, epistatic and sex-specific QTL for body composition in a chicken population divergently selected for low or high growth rate.BMC genomics · 2010Article
- Mapping interacting QTL for count phenotypes using hierarchical Poisson and binomial models: an application to reproductive traits in mice.Genetics research · 2010Article
- Genetic architecture of quantitative traits in mice, flies, and humans.Genome research · 2009Article
- The use of plasmodes as a supplement to simulations: A simple example evaluating individual admixture estimation methodologies.Computational statistics & data analysis · 2009Article
- Hierarchical generalized linear models for multiple quantitative trait locus mapping.Genetics · 2009Article
- Genetic influences on growth and body composition in mice: multilocus interactions.International journal of obesity (2005) · 2009Article
- Genotype X diet interactions in mice predisposed to mammary cancer. I. Body weight and fat.Mammalian genome : official journal of the International Mammalian Genome Society · 2008Article
- Advances in Bayesian multiple quantitative trait loci mapping in experimental crosses.Heredity · 2008Review
- Genetic loci affecting body weight and fatness in a C57BL/6J x PWK/PhJ mouse intercross.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- An efficient Bayesian model selection approach for interacting quantitative trait loci models with many effects.Genetics · 2007Article
Corrections and comments
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Authors and funding
7 authors at 5 institutions in 1 country.
Funding
Abstract
To comprehensively investigate the genetic architecture of growth and obesity, we performed Bayesian analyses of multiple epistatic quantitative trait locus (QTL) models for body weights at five ages (12 days, 3, 6, 9 and 12 weeks) and body composition traits (weights of two fat pads and five organs) in mice produced from a cross of the F1 between M16i (selected for rapid growth rate) and CAST/Ei (wild-derived strain of small and lean mice) back to M16i. Bayesian model selection revealed a temporally regulated network of multiple QTL for body weight, involving both strong main effects and epistatic effects. No QTL had strong support for both early and late growth, although overlapping combinations of main and epistatic effects were observed at adjacent ages. Most main effects and epistatic interactions had an opposite effect on early and late growth. The contribution of epistasis was more pronounced for body weights at older ages. Body composition traits were also influenced by an interacting network of multiple QTLs. Several main and epistatic effects were shared by the body composition and body weight traits, suggesting that pleiotropy plays an important role in growth and obesity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.