Evidence map›Paper›PMID 16545126›Full record

ReviewRetrovirology2006

The retrovirus RNA trafficking granule: from birth to maturity.

Alan W Cochrane, Mark T McNally, Andrew J Mouland

Open access · goldAbstract readReview
In one paragraph

Review in Retrovirology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 81 papers.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 122 citations in OpenAlex.

  1. Review
  2. The RNA Revolution in the Central Molecular Biology Dogma Evolution.International journal of molecular sciences · 2024
    Review
  3. Article
  4. Review
  5. Review
  6. HibeRNAtion: HIV-1 RNA Metabolism and Viral Latency.Frontiers in cellular and infection microbiology · 2022
    Review
  7. Article
  8. Article
  9. Review
  10. Focus on Translation Initiation of the HIV-1 mRNAs.International journal of molecular sciences · 2018
    Review
  11. Review
  12. Article
  13. Article
  14. Subcellular Localization of HIV-1Journal of virology · 2017
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Alan W CochraneDepartment of Medical Genetics and Microbiology, University of Toronto, 1 King's College Circle, Toronto, Ontario, M5S 1A8, Canada. alan.cochrane@utoronto.ca
Mark T McNally
Andrew J Mouland
McGill University · CAMedical College of Wisconsin · USUniversity of Toronto · CA

Funding

RNA SPLICING CONTROL IN ROUS SARCOMA VIRUSR01CA078709 · NCI · MEDICAL COLLEGE OF WISCONSIN · PI MCNALLY, MARK T · 1998 to 2012
$3.2M
NCI NIH HHS R01 CA078709NCI NIH HHS R01 CA78709
6 · The paper itself

Abstract

Post-transcriptional events in the life of an RNA including RNA processing, transport, translation and metabolism are characterized by the regulated assembly of multiple ribonucleoprotein (RNP) complexes. At each of these steps, there is the engagement and disengagement of RNA-binding proteins until the RNA reaches its final destination. For retroviral genomic RNA, the final destination is the capsid. Numerous studies have provided crucial information about these processes and serve as the basis for studies on the intracellular fate of retroviral RNA. Retroviral RNAs are like cellular mRNAs but their processing is more tightly regulated by multiple cis-acting sequences and the activities of many trans-acting proteins. This review describes the viral and cellular partners that retroviral RNA encounters during its maturation that begins in the nucleus, focusing on important events including splicing, 3' end-processing, RNA trafficking from the nucleus to the cytoplasm and finally, mechanisms that lead to its compartmentalization into progeny virions.

Indexed as

Alternative SplicingAnimalsCell NucleusCytoplasmHumansRetroviridaeRNA, MessengerRNA Processing, Post-TranscriptionalRNA TransportRNA, ViralViral ProteinsRNA, MessengerRNA, ViralViral Proteins

Identifiers

PMID16545126
PMCPMC1475878
OpenAlexW1513718978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.