ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2006
cDNA-based gene mapping and GC3 profiling in the soft-shelled turtle suggest a chromosomal size-dependent GC bias shared by sauropsids.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 46 citations in OpenAlex.
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- Elasmobranch genome sequencing reveals evolutionary trends of vertebrate karyotype organization.Genome research · 2023Article
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- Multifaceted Hi-C benchmarking: what makes a difference in chromosome-scale genome scaffolding?GigaScience · 2020Article
- Molecular cytogenetic characterization of repetitive sequences comprising centromeric heterochromatin in three Anseriformes species.PloS one · 2019Article
- The habu genome reveals accelerated evolution of venom protein genes.Scientific reports · 2018Article
- Madagascar ground gecko genome analysis characterizes asymmetric fates of duplicated genes.BMC biology · 2018Article
- Immunofluorescent staining reveals hypermethylation of microchromosomes in the central bearded dragon, Pogona vitticeps.Molecular cytogenetics · 2015Article
- Biased gene conversion and GC-content evolution in the coding sequences of reptiles and vertebrates.Genome biology and evolution · 2014Article
- The bat genome: GC-biased small chromosomes associated with reduction in genome size.Chromosoma · 2013Article
- Molecular cytogenetic map of the central bearded dragon, Pogona vitticeps (Squamata: Agamidae).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2013Article
- Intra-genomic GC heterogeneity in sauropsids: evolutionary insights from cDNA mapping and GC(3) profiling in snake.BMC genomics · 2012Article
- Reassessment of genome size in turtle and crocodile based on chromosome measurement by flow karyotyping: close similarity to chicken.Biology letters · 2012Article
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- Unresolved orthology and peculiar coding sequence properties of lamprey genes: the KCNA gene family as test case.BMC genomics · 2011Article
- Substitution patterns are GC-biased in divergent sequences across the metazoans.Genome biology and evolution · 2011Article
- Contrasting GC-content dynamics across 33 mammalian genomes: relationship with life-history traits and chromosome sizes.Genome research · 2010Article
- Surprising fitness consequences of GC-biased gene conversion: I. Mutation load and inbreeding depression.Genetics · 2010Article
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6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Mammalian and avian genomes comprise several classes of chromosomal segments that vary dramatically in GC-content. Especially in chicken, microchromosomes exhibit a higher GC-content and a higher gene density than macrochromosomes. To understand the evolutionary history of the intra-genome GC heterogeneity in amniotes, it is necessary to examine the equivalence of this GC heterogeneity at the nucleotide level between these animals including reptiles, from which birds diverged. We isolated cDNAs for 39 protein-coding genes from the Chinese soft-shelled turtle, Pelodiscus sinensis, and performed chromosome mapping of 31 genes. The GC-content of exonic third positions (GC3) of P. sinensis genes showed a heterogeneous distribution, and exhibited a significant positive correlation with that of chicken and human orthologs, indicating that the last common ancestor of extant amniotes had already established a GC-compartmentalized genomic structure. Furthermore, chromosome mapping in P. sinensis revealed that microchromosomes tend to contain more GC-rich genes than GC-poor genes, as in chicken. These results illustrate two modes of genome evolution in amniotes: mammals elaborated the genomic configuration in which GC-rich and GC-poor regions coexist in individual chromosomes, whereas sauropsids (reptiles and birds) refined the chromosomal size-dependent GC compartmentalization in which GC-rich genomic fractions tend to be confined to microchromosomes.
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