Evidence map›Paper›PMID 16544051›Full record

ArticleJournal of human genetics2006

Is there any evidence for linkage on chromosome 17cen in affected Japanese sib-pairs with an intracranial aneurysm?

Boris Krischek, Akira Narita, Hiroyuki Akagawa, Hidetoshi Kasuya, Atsushi Tajima, Hideaki Onda, Taku Yoneyama, Tomokatsu Hori, Ituro Inoue

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In one paragraph

Article in Journal of human genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. The genetics of intracranial aneurysms.Journal of human genetics · 2006
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Boris KrischekDivision of Genetic Diagnosis, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. krischek@ims.u-tokyo.ac.jp.
Akira NaritaDivision of Genetic Diagnosis, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Hiroyuki AkagawaDivision of Genetic Diagnosis, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Hidetoshi KasuyaDepartment of Neurosurgery, Neurological Institute, Tokyo Women's Medical University, Tokyo, Japan.
Atsushi TajimaDivision of Genetic Diagnosis, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
Hideaki OndaDepartment of Neurosurgery, Neurological Institute, Tokyo Women's Medical University, Tokyo, Japan.
Taku YoneyamaDepartment of Neurosurgery, Neurological Institute, Tokyo Women's Medical University, Tokyo, Japan.
Tomokatsu HoriDepartment of Neurosurgery, Neurological Institute, Tokyo Women's Medical University, Tokyo, Japan.
Ituro InoueDivision of Genetic Diagnosis, Institute of Medical Science, The University of Tokyo, 4-6-1 Shirokanedai, Minato-ku, Tokyo 108-8639, Japan.
The University of Tokyo · JPTokyo Women's Medical University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A linkage region on chromosome 17cen has previously been found in 29 Japanese families with a history of familial intracranial aneurysms (IA). To investigate whether there is evidence of linkage in affected Japanese sib-pairs we performed nonparametric and parametric linkage analysis of a total of 253 familial aneurysm cases including 111 affected sib-pairs (ASP). Ten microsatellite markers covering a 17.7 cM region were chosen, in accordance with previous work in which nominal P had been below 0.05. Statistical analysis was performed by use of Genehunter and Sibpal software. After calculation of the logarithm of the odds (LOD) and nonparametric linkage analysis (NPL) scores our study did not show any linkage in the region analyzed. Our conclusion did not change even after only ASP were analyzed. In contrast with a previous study examining multigenerational Japanese families with IA, most Japanese ASP may not have a genetic linkage to chromosome 17cen.

Indexed as

Chromosomes, Human, Pair 7Genetic LinkageFemaleGenetic TestingHumansIntracranial AneurysmLod ScoreMalePedigreeSiblings

Identifiers

PMID16544051
OpenAlexW1986596214

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.