ArticleJournal of neurology, neurosurgery, and psychiatry2006
Visuospatial functions in atypical parkinsonian syndromes.
Article in Journal of neurology, neurosurgery, and psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.
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Who cites it
42 citing papers in PubMed, 1 synthesis or guideline pooled it, 103 citations in OpenAlex.
- Retina thickness in atypical parkinsonism: a systematic review and meta-analysis.Journal of neurology · 2022Pooled it
- Longitudinal cognitive outcomes in two progressive supranuclear palsy clinical trials.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Trial
- Cognitive and neuropsychiatric profiles distinguish atypical parkinsonian syndromes.Brain : a journal of neurology · 2025Article
- Language impairment is associated with faster progression in progressive supranuclear palsy-Richardson syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Domain-specific brain regions are associated with cognitive impairment in progressive supranuclear palsy.Neuroimage. Reports · 2025Article
- Current Perspectives on Olfactory Loss in Atypical Parkinsonisms-A Review Article.Biomedicines · 2024Review
- Impaired sequence manipulation in non-demented patients with progressive supranuclear palsy.Brain and behavior · 2024Article
- Retinal Thinning as a Marker of Disease Severity in Progressive Supranuclear Palsy.Journal of movement disorders · 2024Article
- Neural basis of visuospatial tests in behavioral variant frontotemporal dementia.Frontiers in aging neuroscience · 2022Article
- Utility of the Addenbrooke's Cognitive Examination III online calculator to differentiate the primary progressive aphasia variants.Brain communications · 2022Article
- Reduction in Volume of Nucleus Basalis of Meynert Is Specific to Parkinson's Disease and Progressive Supranuclear Palsy but Not to Multiple System Atrophy.Frontiers in aging neuroscience · 2022Article
- Evolving concepts in progressive supranuclear palsy and other 4-repeat tauopathies.Nature reviews. Neurology · 2021Review
- Verbal Short-Term Memory Disturbance in the Primary Progressive Aphasias: Challenges and Distinctions in a Clinical Setting.Brain sciences · 2021Article
- The Value of Sacral Reflex and Sympathetic Skin Reflex in the Diagnosis of Multiple System Atrophy P-Type.Parkinson's disease · 2021Article
- Dopaminergic Basis of Spatial Deficits in Early Parkinson's Disease.Cerebral cortex communications · 2021Article
- Cognition in multiple system atrophy: a single-center cohort study.Annals of clinical and translational neurology · 2020Article
- Visual Object Perception in Premanifest and Early Manifest Huntington's Disease.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2019Article
- Characteristics and progression of cognitive deficits in progressive supranuclear palsy vs. multiple system atrophy and Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Neuroinflammation as a Common Feature of Neurodegenerative Disorders.Frontiers in pharmacology · 2019Review
- Multiple System Atrophy: An Oligodendroglioneural Synucleinopathy1.Journal of Alzheimer's disease : JAD · 2018Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
objectivesVisuospatial deficits have been occasionally reported but never systematically studied in atypical parkinsonian syndromes. The interpretation of existing studies is complicated by the possible influence of motor and frontal executive deficits. Moreover, no attempt has been made to distinguish visuoperceptual from visuospatial tasks. The aim of the present study was to assess visuoperceptual and visuospatial abilities in three atypical parkinsonian syndromes while minimising the influence of confounding variables.
methodsTwenty patients with multiple system atrophy (MSA), 43 with progressive supranuclear palsy (PSP), and 25 with corticobasal degeneration (CBD) as well as 30 healthy age matched controls were examined with the Visual Object and Space Perception Battery (VOSP).
resultsVisuospatial functions were intact in MSA patients. PSP patients showed mild deficits related to general cognitive decline and the severity of oculomotor symptoms. The CBD group showed the most pronounced deficits, with spatial tasks more impaired than object based tasks. Performance on object based, but not spatial, tasks was related to general cognitive status. The extent of the visuospatial impairment could not be predicted from disease duration or severity.
conclusionVisuospatial functions are not consistently impaired in atypical parkinsonian syndromes. The degree and pattern of impairment varies across the diseases, suggesting that the observed deficits could have a different neural basis in each condition. The distinction between the object based ("ventral stream") and the space oriented ("dorsal stream") processing might be useful in the interpretation of visuospatial deficits in parkinsonian syndromes, especially in CBD.
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Registered trials
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