ArticleJournal of neurology, neurosurgery, and psychiatry2006
Clinical and economic results of bilateral subthalamic nucleus stimulation in Parkinson's disease.
Article in Journal of neurology, neurosurgery, and psychiatry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 3 syntheses or guidelines pooled it, 115 citations in OpenAlex.
- Speech, voice, and language outcomes following deep brain stimulation: A systematic review.PloS one · 2024Pooled it
- Subthalamic nucleus and globus pallidus internus stimulation for the treatment of Parkinson's disease: A systematic review.The Journal of international medical research · 2017Pooled it
- Effects of neurostimulation for advanced Parkinson's disease patients on motor symptoms: A multiple-treatments meta-analysas of randomized controlled trials.Scientific reports · 2016Pooled it
- Long-term effects of STN DBS on mood: psychosocial profiles remain stable in a 3-year follow-up.BMC neurology · 2008Trial
- Effects of deep brain stimulation on functional autonomy and quality of life in Parkinson's disease: A systematic review and meta-analysis.Journal of Parkinson's disease · 2026Review
- Comparison of Apathy and Cognitive Symptoms in Pre- and Postoperative Period in Deep Brain Stimulation Surgery.Psychiatry and clinical psychopharmacology · 2023Article
- The Role of Levodopa Challenge in Predicting the Outcome of Subthalamic Deep Brain Stimulation.Movement disorders clinical practice · 2023Article
- Preoperative Levodopa Response and Deep Brain Stimulation Effects on Motor Outcomes in Parkinson's Disease: A Systematic Review.Movement disorders clinical practice · 2022Review
- Subthalamic and pallidal deep brain stimulation for Parkinson's disease-meta-analysis of outcomes.NPJ Parkinson's disease · 2021Article
- Healthcare Utilization and Costs for Patients With Parkinson's Disease After Deep Brain Stimulation.Movement disorders clinical practice · 2019Article
- Periodic flashing coordinated reset stimulation paradigm reduces sensitivity to ON and OFF period durations.PloS one · 2018Article
- Optimizing the deep brain stimulation care pathway in patients with Parkinson's disease.Journal of neurology · 2017Article
- Sociology of Low Expectations: Recalibration as Innovation Work in Biomedicine.Science, technology & human values · 2015Article
- Real life cost and quality of life associated with continuous intraduodenal levodopa infusion compared with oral treatment in Parkinson patients.Journal of neurology · 2014Article
- Restoration of motor function following spinal cord injury via optimal control of intraspinal microstimulation: toward a next generation closed-loop neural prosthesis.Frontiers in neuroscience · 2014Review
- A neurochemical closed-loop controller for deep brain stimulation: toward individualized smart neuromodulation therapies.Frontiers in neuroscience · 2014Article
- Pathways of translation: deep brain stimulation.Clinical and translational science · 2013Review
- Deep brain stimulation in Parkinson's disease.Translational neurodegeneration · 2013Article
- Selecting deep brain stimulation or infusion therapies in advanced Parkinson's disease: an evidence-based review.Journal of neurology · 2013Review
- Timing of deep brain stimulation in Parkinson disease: a need for reappraisal?Annals of neurology · 2013Article
Corrections and comments
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Authors and funding
21 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHigh frequency stimulation of the subthalamic nucleus (STN) is an alternative but expensive neurosurgical treatment for parkinsonian patients with levodopa induced motor complications.
objectiveTo assess the safety, clinical effects, quality of life, and economic cost of STN stimulation.
methodsWe conducted a prospective multicentre study in 95 consecutive Parkinson's disease (PD) patients receiving bilateral STN stimulation and assessed its effects over 12 months. A double blind randomised motor evaluation was carried out at 3 month follow up, and quality of life, self care ability, and predictive factors of outcome following surgery were assessed. The cost of PD was estimated over 6 months before and after surgery.
resultsThe Unified Parkinson's Disease Rating Scale (UPDRS) motor score improved by 57% (p<0.0001) and activities of daily living improved by 48% (p<0.0001) at 12 month follow up. Double blind motor scoring improved by 51% at 3 month follow up (p<0.0001). The total PD Quality of Life Questionnaire (PDQL-37) score improved by 28% (p<0.001). The better the preoperative motor score after a levodopa challenge, the better the outcome after STN stimulation. Five patients developed an intracerebral haematoma during electrode implantation with permanent after effects in two. The 6 month costs of PD decreased from 10,087 euros before surgery to 1673 euros after surgery (p<0.0001) mainly because of the decrease in medication. These savings allowed a return on the procedure investment, estimated at 36,904 euros over 2.2 years.
conclusionsSTN stimulation has good outcomes with relatively low risk and little cost burden in PD patients with levodopa induced motor complications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.