ArticleGenes & development2006
Multipotential differentiation ability of GATA-1-null erythroid-committed cells.
Article in Genes & development, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Review
- Data-driven modeling predicts gene regulatory network dynamics during the differentiation of multipotential hematopoietic progenitors.PLoS computational biology · 2022Article
- SteamedFrontiers in pharmacology · 2019Article
- Modeling dynamic functional relationship networks and application to ex vivo human erythroid differentiation.Bioinformatics (Oxford, England) · 2014Article
- Transcription factor GATA1 is dispensable for mast cell differentiation in adult mice.Molecular and cellular biology · 2014Article
- Transcriptional regulation by GATA1 and GATA2 during erythropoiesis.International journal of hematology · 2011Article
- Combinatorial motif analysis of regulatory gene expression in Mafb deficient macrophages.BMC systems biology · 2011Article
- SENP1-mediated GATA1 deSUMOylation is critical for definitive erythropoiesis.The Journal of experimental medicine · 2010Article
- Article
- Forcing cells to change lineages.Nature · 2009Review
- Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate.Blood · 2009Article
- Article
- Hematopoietic stem cells: the paradigmatic tissue-specific stem cell.The American journal of pathology · 2006Article
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
GATA-1, a zinc finger transcription factor, has been believed to be indispensable for the survival of proerythroblasts. However, we found that GATA-1-null proerythroblasts could survive and proliferate on OP9 stroma cells in the presence of erythropoietin. Furthermore, myeloid and mast cells were induced from the GATA-1-null proerythroblasts by the stimulation of granulocyte-macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3), respectively, but lymphoid differentiation was not achieved by in vivo transfer. Thus, without activity of the transcription factor required for terminal differentiation, even relatively mature and committed cells proliferate continuously with the differentiation capacity to other lineages. Our data suggest that GATA-1 is a critical transcription factor to fix erythroid progenitors to the erythroid lineage.
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