ArticleClinical and experimental immunology2006
Peripheral T lymphocytes from patients with early systemic sclerosis co-cultured with autologous fibroblasts undergo an oligoclonal expansion similar to that occurring in the skin.
Article in Clinical and experimental immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Antigen-presenting fibroblasts: emerging players in immune modulation and therapeutic targets.Theranostics · 2025Review
- Characterising the autoantibody repertoire in systemic sclerosis following myeloablative haematopoietic stem cell transplantation.Annals of the rheumatic diseases · 2023Article
- A Mechanistic Insight into the Pathogenic Role of Interleukin 17A in Systemic Autoimmune Diseases.Mediators of inflammation · 2022Review
- TFH cells in systemic sclerosis.Journal of translational medicine · 2021Review
- DNA methylation patterns in juvenile systemic sclerosis and localized scleroderma.Clinical immunology (Orlando, Fla.) · 2021Article
- T-Cell Proapoptotic and Antifibrotic Activity Against Autologous Skin FibroblastsFrontiers in immunology · 2020Article
- Clinical correlates of human leucocyte antigen (HLA)-G in systemic sclerosis.Clinical and experimental immunology · 2015Article
- Autoantibodies recognizing the amino terminal 1-17 segment of CENP-A display unique specificities in systemic sclerosis.PloS one · 2013Article
- Apoptosis modulation as a promising target for treatment of systemic sclerosis.International journal of rheumatology · 2011Article
- Autoimmunity in systemic sclerosis: current concepts.Current rheumatology reports · 2007Review
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Authors and funding
6 authors.
Funding
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Abstract
In recent years several reports have suggested that T cells may have a role in systemic sclerosis (SSc). The aim of our study was to investigate the dynamics of T cell repertoire in early SSc disease analysing a target organ, the skin, and the peripheral blood. To date, indeed, it is not clear if T cell expansions found in SSc reflect a general activation or result from specific antigen stimulation in the target organs. This is an important point to assess in order to characterize the role of T cells in the development of SSc. To address these questions we studied T cell repertoire by CDR3 length analysis in skin biopsies and peripheral blood obtained from patients affected by SSc and we found that a skewed T cell repertoire was present only in the biopsies. In order to characterize more effectively the meaning of these data, we performed co-cultures using fibroblasts and peripheral blood mononuclear cells (PBMCs) obtained from SSc patients. These experiments showed that same T cell expansions were detectable in the skin of SSc patients and in the cultures of PBMCs and autologous fibroblasts of the patients but not in their peripheral blood. Taken together, these data suggest that fibroblasts trigger specific T cell expansions in the early phase of SSc.
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