ArticleClinical and experimental immunology2006
Interleukin 18 and human immunodeficiency virus type I infection in adolescents and adults.
Article in Clinical and experimental immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Extracellular condensates (ECs) are endogenous modulators of HIV transcription and latency reactivation.Molecular psychiatry · 2026Article
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- Early on-treatment plasma interleukin-18 as a promising indicator for long-term virological response in patients with HIV-1 infection.Frontiers in medicine · 2023Article
- HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation.PloS one · 2018Article
- Insufficient natural killer cell responses against retroviruses: how to improve NK cell killing of retrovirus-infected cells.Retrovirology · 2016Review
- The Effect of Rosuvastatin on Markers of Immune Activation in Treatment-Naive Human Immunodeficiency Virus-Patients.Open forum infectious diseases · 2016Article
- IL-18 Gene Promoter Region 607C/A Polymorphism in HIV-1 Infected North Indian Population.Balkan journal of medical genetics : BJMG · 2011Article
- Identification of three immunologic correlates for HIV type 1 pathogenesis in youth.AIDS research and human retroviruses · 2011Article
- Dense mapping of IL18 shows no association in SLE.Human molecular genetics · 2011Article
- Interleukin-18 predicts atherosclerosis progression in SIV-infected and uninfected rhesus monkeys (Macaca mulatta) on a high-fat/high-cholesterol diet.Laboratory investigation; a journal of technical methods and pathology · 2009Article
- Potential role of interleukin-18 in the immunopathogenesis of AIDS: involvement in fratricidal killing of NK cells.Journal of virology · 2009Article
- Host factors influencing susceptibility to HIV infection and AIDS progression.Retrovirology · 2007Review
- CCL3L1 and CCL4L1: variable gene copy number in adolescents with and without human immunodeficiency virus type 1 (HIV-1) infection.Genes and immunity · 2007Article
- The role of cytokines in the establishment, persistence and eradication of the HIV reservoir.Cytokine & growth factor reviewsReview
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Interleukin (IL)-18, a proinflammatory cytokine, has been recognized recently as an important factor in both treated and untreated patients with human immunodeficiency virus type 1 (HIV-1) infection. Consistent with all earlier reports, our quantification of serum IL-18 concentrations in 88 HIV-1 seropositive, North American adolescents (14-18 years old) revealed a positive correlation with cell-free HIV-1 viral load at two separate visits (Spearman's r = 0.31 and 0.50, respectively, P < 0.01 for both), along with a negative correlation with CD4+ T cell counts (r = -0.31 and -0.35, P < 0.01 for both). In additional analyses of 66 adults (21-58 years old) from Zambia, HIV-1 seroconversion was associated uniformly with elevated IL-18 production (P < 0.0001). These epidemiological relationships were independent of other population-related characteristics, including age, gender and ethnicity. In neither study population could serum IL-18 concentrations be associated with the IL-18 gene (IL18) promoter genotypes defined by five major single nucleotide polymorphisms. Collectively, these findings suggest that circulating IL-18 rather than the IL18 genotype may provide a useful biomarker for HIV-1-related events or outcomes.
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