ArticleClinical and experimental immunology2006
Association of rheumatoid factor production with FcgammaRIIIa polymorphism in Taiwanese rheumatoid arthritis.
Article in Clinical and experimental immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 32 citations in OpenAlex.
- Association ofFrontiers in immunology · 2025Pooled it
- High-affinity FcγRIIIa genetic variants and potent NK cell-mediated antibody-dependent cellular cytotoxicity (ADCC) responses contributing to severe COVID-19.Genetics in medicine : official journal of the American College of Medical Genetics · 2022Article
- Transmembrane domain dependent inhibitory function of FcγRIIB.Protein & cell · 2018Review
- Spontaneous germinal centers and autoimmunity.Autoimmunity · 2017Review
- Identification of rheumatoid arthritis biomarkers based on single nucleotide polymorphisms and haplotype blocks: A systematic review and meta-analysis.Journal of advanced research · 2016Review
- MUTYH Gene Polymorphisms as Risk Factors for Rheumatoid Arthritis.BioMed research international · 2015Article
- Fcγ receptor IIIa single-nucleotide polymorphisms and haplotypes affect human IgG binding and are associated with lupus nephritis in African Americans.Arthritis & rheumatology (Hoboken, N.J.) · 2014Article
- Association of FcγRIIa R131H polymorphism with idiopathic pulmonary fibrosis severity and progression.BMC pulmonary medicine · 2010Article
- The levels of CD16/Fc gamma receptor IIIA on CD14+ CD16+ monocytes are higher in children with severe Plasmodium falciparum anemia than in children with cerebral or uncomplicated malaria.Infection and immunity · 2010Article
- Functional and clinical consequences of Fc receptor polymorphic and copy number variants.Clinical and experimental immunology · 2009Review
- IgM, IgG, and IgA rheumatoid factors in pigeon hypersensitivity pneumonitis.Journal of clinical laboratory analysis · 2007Article
- High synovial expression of the inhibitory FcgammaRIIb in rheumatoid arthritis.Arthritis research & therapy · 2007Article
- Rheumatoid peripheral blood phagocytes are primed for activation but have impaired Fc-mediated generation of reactive oxygen species.Arthritis research & therapy · 2007Article
- The complex role of Fcgamma receptors in the pathology of arthritis.Springer seminars in immunopathology · 2006Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fcgamma receptors (FcgammaR) impact upon the development of inflammatory arthritis through immune complex stimulation and proinflammatory cytokine production. FcgammaRIIa, FcgammaRIotaIotaIotaa and FcRgammaIIIb polymorphisms were genotyped in 212 rheumatoid arthritis (RA) patients and 371 healthy control subjects using an allelic-specific polymerase chain reaction (PCR). No significant skewing in the distribution of FcgammaRIIa H/R131, FcgammaRIIIa F/V158 and FcgammaRIIIb NA1/NA2 was found between RA patients and healthy control subjects. However, a significant skewing distribution of the FcgammaRIIIa F/V158 polymorphism was observed between rheumatoid factor (RF)-positive versus RF-negative RA patients (P = 0.01). The low-affinity FcgammaRIIIa F158 allele seems to have a protective role in RF production, in comparison with the FcgammaRIIIa V158 allele (P = 0.004; OR = 0.485; 95% CI: 0.293-0.803). A high frequency of FcgammaRIIIa F/F158 was identified in RA patients with negative RF compared with RF-positive patients (for FF158 versus FV158 + VV158; P = 0.002; OR = 0.372; 95% CI: 0.194-0.713). In addition, no association was found between FcgammaRIIa H/R131, FcgammaRhoIIIa F/V158 and FcgammaRIIIb NA1/NA2 polymorphisms and other clinical parameters. The results of this study suggest that three activating FcgammaRs polymorphisms lack association with RA but FcgammaIIIa F/V158 polymorphism may influence RF production and IgG RF immune complex handling in Taiwanese RA patients.
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