Trial reportBritish journal of clinical pharmacology2006
Hyperalgesia induced by cutaneous freeze injury for testing analgesics in healthy volunteers.
Trial report in British journal of clinical pharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Human surrogate models of central sensitization: A critical review and practical guide.European journal of pain (London, England) · 2021Pooled it
- A comparison of ketamine and paracetamol for preventing remifentanil induced hyperalgesia in patients undergoing total abdominal hysterectomy.International journal of medical sciences · 2012Trial
- A novel model of inflammatory pain in human skin involving topical application of sodium lauryl sulfate.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Trial
- A literature review on the pharmacological sensitivity of human evoked hyperalgesia pain models.British journal of clinical pharmacology · 2016Review
- No association of polymorphisms in the serotonin transporter gene with thermal pain sensation in healthy individuals.Molecular pain · 2014Article
- Sampling times and genotyping concerns in bioequivalence evaluation of branded and generic formulations.Therapeutics and clinical risk management · 2013Article
- Comparative pharmacokinetic and pharmacodynamic evaluation of branded and generic formulations of meloxicam in healthy male volunteers.Therapeutics and clinical risk management · 2013Article
- Human experimental pain models: A review of standardized methods in drug development.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012Article
- A simple contact heat experimental pain model for evaluation of analgesic agents in healthy volunteers.Current therapeutic research, clinical and experimental · 2011Article
- Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers: an updated review.British journal of clinical pharmacology · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsThe early phases of the clinical development of new analgesic agents are severely hindered by a lack of reliable sensitive tests based on experimental pain models. The aim of this study was to assess the ability of a localized hyperalgesia model induced by cutaneous freeze injury to evaluate the pharmacodynamic profile of weak analgesic agents in healthy volunteers. METHOD AND
resultsTwo groups of 24 healthy volunteers were enrolled in controlled, randomized, double-blind, cross-over studies. After freeze injury, punctate mechanical pain thresholds (MPT) were measured over three consecutive daily sessions to characterize the induced hyperalgesia and compare the effects of (i) oral ibuprofen and acetaminophen and (ii) oral and topical ibuprofen vs. placebo. The freeze injury model provides two types of hyperalgesia, primary and secondary, stable over 72 h. The MPT values (means; 95% confidence interval) in the primary (38.9 g; 34.3, 43.5) and secondary (82.2 g; 81.4, 88.0) areas of hyperalgesia were different from normal skin (107.5 g; 101.5, 115.2). This model clearly showed the antihyperalgesic effect of both systemic and topical ibuprofen (42.1%; 26.6, 61.2 and 33.8%; 16.4, 51.2 of MPT increase, respectively) but not that of acetaminophen.
conclusionCutaneous freeze injury coupled with a von Frey electronic device to assess the mechanical pain threshold is a convenient model that causes no discomfort. The improved sensitivity and stability of this experimental model of hyperalgesia over three consecutive days make it a useful tool for evaluating the efficacy and detecting the potential sites of action of analgesic agents such as nonsteroidal anti-inflammatory drugs in healthy human subjects.
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