ArticleImmunogenetics2006
Bovine T cell receptor gamma variable and constant genes: combinatorial usage by circulating gammadelta T cells.
Article in Immunogenetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 42 citations in OpenAlex.
- IMGTAntibodies (Basel, Switzerland) · 2026Review
- From benchmarking alignment of genome assemblies to IMGT annotation: the paradigm of the bovine Bos taurus T cell receptor (TRG) locus.BMC genomics · 2025Article
- IMGTBiomolecules · 2022Article
- Transcriptional dynamics and epigenetic regulation of E and ID protein encoding genes during human T cell development.Frontiers in immunology · 2022Article
- The expansion of the TRB and TRG genes in domestic goats (Capra hircus) is characteristic of the ruminant species.BMC genomics · 2020Article
- Immunoglobulins or Antibodies: IMGTBiomedicines · 2020Review
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- Beyond mice and men: environmental change, immunity and infections in wild ungulates.Parasite immunology · 2015Article
- Spectratype analysis of the T cell receptor δ CDR3 region of bovine γδ T cells responding to leptospira.Immunogenetics · 2015Article
- Vγ9 and Vδ2 T cell antigen receptor genes and butyrophilin 3 (BTN3) emerged with placental mammals and are concomitantly preserved in selected species like alpaca (Vicugna pacos).Immunogenetics · 2014Article
- Evolutionarily conserved TCR binding sites, identification of T cells in primary lymphoid tissues, and surprising trans-rearrangements in nurse shark.Journal of immunology (Baltimore, Md. : 1950) · 2010Article
- Annotation and classification of the bovine T cell receptor delta genes.BMC genomics · 2010Article
- Characterization of arrangement and expression of the T cell receptor gamma locus in the sandbar shark.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Genomic organization and recombinational unit duplication-driven evolution of ovine and bovine T cell receptor gamma loci.BMC genomics · 2008Article
- Molecular in situ hybridization analysis of sheep and goat BAC clones identifies the transcriptional orientation of T cell receptor gamma genes on chromosome 4 in bovids.Veterinary research communications · 2007Article
- Identification of three new bovine T-cell receptor delta variable gene subgroups expressed by peripheral blood T cells.Immunogenetics · 2006Article
- Differential TCR gene usage between WC1- and WC1+ ruminant gammadelta T cell subpopulations including those responding to bacterial antigen.Immunogenetics · 2006Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies here describe expression and sequence of several new bovine T cell receptor gamma (TRG) genes to yield a total of 11 TRG variable (TRGV) genes (in eight subgroups) and six TRG constant (TRGC) genes. Publicly available genomic sequences were annotated to show their placement. Homologous TRG genes in cattle and sheep were assigned, using four accepted criteria. New genes described here include the bovine TRGC6, TRGV2, and TRGV4, homologues of ovine TRGC4, TRGV2, and TRGV4, respectively. The bovine Vgamma7 and BTGV1 clones (previously TRGV4 and TRGV2, respectively) were reassigned to new subgroups TRGV7 and TRGV8, respectively, with approval by the IMGT Nomenclature Committee. Three TRGV subgroups (TRGV5, TRGV6, and TRGV8) were further designated as TRGV5-1 and TRGV5-2, TRGV6-1 and TRGV6-2, and TRGV8-1 and TRGV8-2 because each subgroup is comprised of two mapped genes. The complete sequence of bovine TRGC5 is also reported, for which a limited number of nucleotides was previously available, and shown to be most closely related to ovine TRGC5. Analysis of circulating gammadelta T cells revealed that rearrangement of TRGV genes with TRGC genes is largely dictated by their proximity within one of the six genomic V-J-C cassettes, with all TRG genes expressed by bovine peripheral blood gammadelta T cells. Cattle are useful models for gammadelta T cell biology because they have gammadelta T cells that respond to isopentenylpyrophosphate (IPP) antigens, while mice do not, and some bovine TRGV genes cluster closely with human genes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.