ArticleImmunogenetics2006
Variable domains in hagfish: NICIR is a polymorphic multigene family expressed preferentially in leukocytes and is related to lamprey TCR-like.
Article in Immunogenetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 33 citations in OpenAlex.
- An Ancient MHC-Linked Gene Encodes a Nonrearranging Shark Antibody, UrIg, Convergent with IgG.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- On the relationship between extant innate immune receptors and the evolutionary origins of jawed vertebrate adaptive immunity.Immunogenetics · 2022Review
- The immune system of jawless vertebrates: insights into the prototype of the adaptive immune system.Immunogenetics · 2021Review
- An inhibitory receptor of VLRB in the agnathan lamprey.Scientific reports · 2016Article
- Molecular cloning, expression pattern, and molecular evolution of the spleen tyrosine kinase in lamprey, Lampetra japonica.Development genes and evolution · 2015Article
- Re-evaluation of the immunological Big Bang.Current biology : CB · 2014Review
- A major allogenic leukocyte antigen in the agnathan hagfish.Scientific reports · 2013Article
- Evolution of the B7 family: co-evolution of B7H6 and NKp30, identification of a new B7 family member, B7H7, and of B7's historical relationship with the MHC.Immunogenetics · 2012Article
- Immune related genes underpin the evolution of adaptive immunity in jawless vertebrates.Current genomics · 2012Article
- Genome biology of the cyclostomes and insights into the evolutionary biology of vertebrate genomes.Integrative and comparative biology · 2010Article
- Origin and evolution of the adaptive immune system: genetic events and selective pressures.Nature reviews. Genetics · 2010Review
- Inhibitory signaling potential of a TCR-like molecule in lamprey.European journal of immunology · 2009Article
- Immunoglobulin variable regions in molecules exhibiting characteristics of innate and adaptive immune receptors.Immunologic research · 2007Article
- Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus.Nature immunology · 2006Article
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The jawless vertebrates, represented by hagfish and lampreys, are the most advanced animals that apparently lack T cell and B cell receptors. As such, they offer unique opportunities for understanding the evolution of antigen receptors and variable (V)-type immunoglobulin (Ig)-like domains. In the present study, we describe four hagfish Ig superfamily (IgSF) members carrying V-type domains. None of them appeared to have direct counterparts in jawed vertebrates, indicating that many IgSF molecules have either evolved independently in jawed and jawless vertebrates or diverged to the extent that clear homology is no longer recognizable. One of the members encoded a molecule closely related to the previously described membrane protein designated novel ITAM (immunoreceptor tyrosine-based activation motif)-containing IgSF receptors (NICIR). We show here that NICIR is a polymorphic multigene family with at least three members and is expressed predominantly in peripheral blood leukocytes. Phylogenetic analysis indicates that among known proteins, NICIR is most closely related to the lamprey molecule recently proposed to be a potential ancestor of T cell receptors.
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