ArticlePsychopharmacology2006
Search for correlations between serotonin 5-HT1A receptor expression and cognitive functions--a strategy in translational psychopharmacology.
Article in Psychopharmacology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Targeting the serotonergic system in the treatment of neurodegenerative diseases-emerging therapies and unmet challenges.Pharmacological reviews · 2025Review
- Associations Between Cognition and Serotonin 1B Receptor Availability in Healthy Volunteers: A [11C]AZ10419369 Positron Emission Tomography Study.The international journal of neuropsychopharmacology · 2023Article
- RETRACTED: Activating SIRT-1 Signalling with the Mitochondrial-CoQ10 Activator Solanesol Improves Neurobehavioral and Neurochemical Defects in Ouabain-Induced Experimental Model of Bipolar Disorder.Pharmaceuticals (Basel, Switzerland) · 2022Article
- Cognitive Function and Monoamine Neurotransmission in Schizophrenia: Evidence From Positron Emission Tomography Studies.Frontiers in psychiatry · 2018Review
- Differential modulation of the default mode network via serotonin-1A receptors.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Blockade of 5-HT2 receptor selectively prevents MDMA-induced verbal memory impairment.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2011Article
- Cognitive function is related to fronto-striatal serotonin transporter levels--a brain PET study in young healthy subjects.Psychopharmacology · 2011Article
- Escitalopram enhances the association of serotonin-1A autoreceptors to heteroreceptors in anxiety disorders.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- 5-HT(1A) receptor function in major depressive disorder.Progress in neurobiology · 2009Review
- A PET study on regional coexpression of 5-HT1A receptors and 5-HTT in the human brain.Psychopharmacology · 2007Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
rationaleAnimal studies and studies of human aging have suggested that the serotonin 5-HT1A receptor may serve as a biomarker for cognitive functioning and a target for pharmacological treatment of cognitive deficits.
objectivesThe purpose of this positron emission tomography (PET) study was to search for relationships between interindividual variability in serotonin 5-HT1A receptor binding potential (BP) and cognitive functioning. MATERIALS AND
methodsTwenty-four male control subjects, age 20-55 years, were examined with [11C]WAY100635 PET and a battery of cognitive tests. 5-HT1A receptor binding potential were calculated for the raphe nuclei, the hippocampus and the neocortex. Correlation coefficients between BP and cognitive performance were obtained for each region.
resultsThere was a severalfold of variability in 5-HT1A BP between individuals. We found no significant correlation between regional [11C]WAY100635 binding and cognitive performance.
conclusionsThe results do not provide support for involvement of the 5-HT1A receptor in cognitive functioning in man and question the predictive validity of some currently used animal models in translational neuroscience.
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Registered trials
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