ArticleThe EMBO journal2006
Regulation of RNA polymerase III transcription during hypertrophic growth.
Article in The EMBO journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 66 citations in OpenAlex.
- An RNA polymerase III tissue and tumor atlas uncovers context-specific activities linked to 3D epigenome regulatory mechanisms.bioRxiv : the preprint server for biology · 2025Article
- Eukaryotic cell size regulation and its implications for cellular function and dysfunction.Physiological reviews · 2024Review
- Antitumor mechanisms and future clinical applications of the natural product triptolide.Cancer cell international · 2024Review
- Downregulation of Brf1 Induces Liver Failure and Inhibits Hepatocellular Carcinoma Progression by Promoting Apoptosis.Journal of Cancer · 2024Article
- Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture.Genome biology · 2022Article
- tRNA dysregulation and disease.Nature reviews. Genetics · 2022Review
- RNA polymerase III transcription and cancer: A tale of two RPC7 subunits.Frontiers in molecular biosciences · 2022Review
- Role of betaine in inhibiting the induction of RNA Pol III gene transcription and cell growth caused by alcohol.Chemico-biological interactions · 2020Article
- The significance of Runx2 mediating alcohol-induced Brf1 expression and RNA Pol III gene transcription.Chemico-biological interactions · 2020Article
- Inhibition of tRNA Gene Transcription by the Immunosuppressant Mycophenolic Acid.Molecular and cellular biology · 2019Article
- Brf1 loss and not overexpression disrupts tissues homeostasis in the intestine, liver and pancreas.Cell death and differentiation · 2019Article
- Inhibition of RNA polymerase III transcription by Triptolide attenuates colorectal tumorigenesis.Journal of experimental & clinical cancer research : CR · 2019Article
- Maf1 ameliorates cardiac hypertrophy by inhibiting RNA polymerase III through ERK1/2.Theranostics · 2019Article
- Alcohol Intake and Abnormal Expression of Brf1 in Breast Cancer.Oxidative medicine and cellular longevity · 2019Review
- Role of Brf1 interaction with ERα, and significance of its overexpression, in human breast cancer.Molecular oncology · 2017Article
- Abnormal expression of TFIIIB subunits and RNA Pol III genes is associated with hepatocellular carcinoma.Liver research (Beijing, China) · 2017Article
- Article
- Correlation between Ribosome Biogenesis and the Magnitude of Hypertrophy in Overloaded Skeletal Muscle.PloS one · 2016Article
- Alteration of BRCA1 expression affects alcohol-induced transcription of RNA Pol III-dependent genes.Gene · 2015Article
- Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells.Oncotarget · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
The cell division-independent growth of terminally differentiated cardiomyocytes is commonly associated with cardiovascular disease. We demonstrate that it is accompanied by a substantial rise in transcription by RNA polymerase (pol) III, which produces essential components of the biosynthetic apparatus, including 5S rRNA and tRNAs. This increase in transcription is achieved by changes in both the activity and level of the essential pol III-specific transcription factor TFIIIB. Erk and c-Myc, which directly activate TFIIIB in proliferating fibroblasts, also induce pol III transcription in growing cardiomyocytes. Furthermore, hypertrophic stimulation increases expression of the essential TFIIIB subunit Brf1, an effect not seen when fibroblasts proliferate. Erk mediates this induction of Brf1 expression and therefore contributes in at least two ways to pol III transcriptional activation during hypertrophy. Increased production of tRNA and 5S rRNA will contribute to the enhanced translational capacity required to sustain hypertrophic growth.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.