ArticleDevelopment (Cambridge, England)2006
smoothened and thickveins regulate Moleskin/Importin 7-mediated MAP kinase signaling in the developing Drosophila eye.
Article in Development (Cambridge, England), 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Importin-7 mediates memory consolidation through regulation of nuclear translocation of training-activated MAPK in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A systems-level interrogation identifies regulators of Drosophila blood cell number and survival.PLoS genetics · 2015Article
- Stimulated nuclear import by β-like importins.F1000prime reports · 2013Review
- Hox proteins coordinate peripodial decapentaplegic expression to direct adult head morphogenesis in Drosophila.Developmental biology · 2012Article
- Moleskin is essential for the formation of the myotendinous junction in Drosophila.Developmental biology · 2011Article
- Importin-beta11 regulates synaptic phosphorylated mothers against decapentaplegic, and thereby influences synaptic development and function at the Drosophila neuromuscular junction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Nuclear entry of activated MAPK is restricted in primary ovarian and mammary epithelial cells.PloS one · 2010Article
- C-Fos elimination compensates for disabled-2 requirement in mouse extraembryonic endoderm development.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Identification of novel regulators of atonal expression in the developing Drosophila retina.Genetics · 2008Article
- Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins.Molecular & cellular proteomics : MCP · 2008Article
- Nuclear localization of the ERK MAP kinase mediated by Drosophila alphaPS2betaPS integrin and importin-7.Molecular biology of the cell · 2007Article
- Msk is required for nuclear import of TGF-{beta}/BMP-activated Smads.The Journal of cell biology · 2007Article
- Delta and Egfr expression are regulated by Importin-7/Moleskin in Drosophila wing development.Developmental biology · 2007Article
- Intracellular mediators of transforming growth factor beta superfamily signaling localize to endosomes in chicken embryo and mouse lenses in vivo.BMC cell biology · 2007Article
- A genetic screen in Drosophila for genes interacting with senseless during neuronal development identifies the importin moleskin.Genetics · 2007Article
- "Importin" signaling roles for import proteins: the function of Drosophila importin-7 (DIM-7) in muscle-tendon signaling.Cell adhesion & migrationArticle
- Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The Drosophila Mitogen Activated Protein Kinase (MAPK) Rolled is a key regulator of developmental signaling, relaying information from the cytoplasm into the nucleus. Cytoplasmic MEK phosphorylates MAPK (pMAPK), which then dimerizes and translocates to the nucleus where it regulates transcription factors. In cell culture, MAPK nuclear translocation directly follows phosphorylation, but in developing tissues pMAPK can be held in the cytoplasm for extended periods (hours). Here, we show that Moleskin antigen (Drosophila Importin 7/Msk), a MAPK transport factor, is sequestered apically at a time when lateral inhibition is required for patterning in the developing eye. We suggest that this apical restriction of Msk limits MAPK nuclear translocation and blocks Ras pathway nuclear signaling. Ectopic expression of Msk overcomes this block and disrupts patterning. Additionally, the MAPK cytoplasmic hold is genetically dependent on the presence of Decapentaplegic (Dpp) and Hedgehog receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.