ArticleThe British journal of ophthalmology2006
Increased relative mitochondrial DNA content in leucocytes of patients with NAION.
Article in The British journal of ophthalmology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- 40 Hz flicker preconditioning protects nonarteritic anterior ischemic optic neuropathy via adenosine signaling.Communications biology · 2026Article
- Nonarteritic anterior ischemic optic neuropathy and incidence of Parkinson's disease based on a nationwide population based study.Scientific reports · 2024Article
- Oxidative Stress in Optic Neuropathies.Antioxidants (Basel, Switzerland) · 2021Review
- Genetic Aspects of Keratoconus: A Literature Review Exploring Potential Genetic Contributions and Possible Genetic Relationships with Comorbidities.Ophthalmology and therapy · 2018Review
- An overview of the Prince Salman Center for Disability Research scientific outcomes.Saudi medical journal · 2014Article
- Keratoconus is associated with increased copy number of mitochondrial DNA.Molecular vision · 2014Article
- Iron homeostasis and eye disease.Biochimica et biophysica acta · 2009Review
- Analysis of nuclear and mitochondrial genes in patients with pseudoexfoliation glaucoma.Molecular vision · 2008Article
- Cardiac-targeted transgenic mutant mitochondrial enzymes: mtDNA defects, antiretroviral toxicity and cardiomyopathy.Cardiovascular toxicology · 2008Article
- Mitochondrial DNA abnormalities in NAION.The British journal of ophthalmology · 2007Article
- The role of mitochondria in health, ageing, and diseases affecting vision.The British journal of ophthalmology · 2006Article
- Retinal nerve fiber layer thickness in children with β-thalassemia major.Saudi journal of ophthalmology : official journal of the Saudi Ophthalmological SocietyArticle
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Abstract
aimTo investigate possible changes in relative mitochondrial DNA (mtDNA) content in patients with non-arteritic anterior ischaemic optic neuropathy (NAION).
methods19 patients with NAION were compared to 32 controls matched for age, sex distribution, and ethnicity. DNA was extracted from leucocytes and competitive multiplex polymerase chain reaction was carried out with two primer pairs (one pair for mtDNA ND1 gene and the other pair for beta actin nuclear gene) in the presence of a fluorescent dye.
resultsThe mean relative mtDNA content in controls (0.93 (SD 0.11); 95% CI 0.89 to 0.97) was significantly less than in NAION patients (2.40 (1.05); 95% CI 1.90 to 2.91; p < 0.001). Relative mtDNA content was negatively correlated with Snellen visual acuity (Spearman's rho; r = -0.37; p = 0.022).
conclusionIncreased relative mtDNA content in NAION patients may imply a response to oxidative stress, possibly in part because of mitochondrial respiratory chain defects. Significantly more non-synonymous mtDNA nucleotide changes, significantly increased relative mtDNA content, and a significant association between relative mtDNA content and visual acuity all imply that mitochondrial abnormalities may be a risk factor for NAION.
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