ArticleJournal of the American Society for Mass Spectrometry2006
Comparative studies of 193-nm photodissociation and TOF-TOFMS analysis of bradykinin analogues: the effects of charge site(s) and fragmentation timescales.
Article in Journal of the American Society for Mass Spectrometry, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 46 citations in OpenAlex.
- Ultraviolet photodissociation and collision-induced dissociation for qualitative/quantitative analysis of low molecular weight compounds by liquid chromatography-mass spectrometry.Analytical and bioanalytical chemistry · 2023Article
- Quantitative Assessment of Six Different Reagent Gases for Charge Transfer Dissociation (CTD) of Biological Ions.International journal of mass spectrometry · 2021Article
- Ultraviolet Photodissociation Mass Spectrometry for Analysis of Biological Molecules.Chemical reviews · 2020Review
- Comparison of Glycopeptide Fragmentation by Collision Induced Dissociation and Ultraviolet Photodissociation.International journal of mass spectrometry · 2015Article
- Top-Down Strategies for the Structural Elucidation of Intact Gram-negative Bacterial Endotoxins.Chemical science · 2014Article
- Photodissociation mass spectrometry: new tools for characterization of biological molecules.Chemical Society reviews · 2014Review
- 193 nm ultraviolet photodissociation mass spectrometry for the structural elucidation of lipid A compounds in complex mixtures.Analytical chemistry · 2014Article
- Structural characterization of gangliosides and glycolipids via ultraviolet photodissociation mass spectrometry.Analytical chemistry · 2013Article
- Complete protein characterization using top-down mass spectrometry and ultraviolet photodissociation.Journal of the American Chemical Society · 2013Article
- Systematic comparison of ultraviolet photodissociation and electron transfer dissociation for peptide anion characterization.Journal of the American Society for Mass Spectrometry · 2012Article
- Photodissociation of charge tagged peptides.Journal of the American Society for Mass Spectrometry · 2012Article
- Charge-site-dependent dissociation of hydrogen-rich radical peptide cations upon vacuum UV photoexcitation.Chemistry (Weinheim an der Bergstrasse, Germany) · 2012Article
- Electron induced dissociation of singly deprotonated peptides.Journal of the American Society for Mass Spectrometry · 2011Article
- Ultrafast ultraviolet photodissociation at 193 nm and its applicability to proteomic workflows.Journal of proteome research · 2010Article
- On the zwitterionic nature of gas-phase peptides and protein ions.PLoS computational biology · 2010Article
- Peptide photodissociation with 157 nm light in a commercial tandem time-of-flight mass spectrometer.Analytical chemistry · 2009Article
- Time-resolved photodissociation of singly protonated peptides with an arginine at the N-terminus: a statistical interpretation.Journal of the American Society for Mass Spectrometry · 2008Article
- Photodissociation of non-covalent peptide-crown ether complexes.Journal of the American Society for Mass Spectrometry · 2008Article
- Development of a time-resolved method for photodissociation mechanistic study of protonated peptides: use of a voltage-floated cell in a tandem time-of-flight mass spectrometer.Journal of the American Society for Mass Spectrometry · 2007Article
- Factors that impact the vacuum ultraviolet photofragmentation of peptide ions.Journal of the American Society for Mass Spectrometry · 2007Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dissociation reactions of [M + H]+, [M + Na]+, and [M + Cu]+ ions of bradykinin (amino acid sequence RPPGFSPFR) and three bradykinin analogues (RPPGF, RPPGFSPF, PPGFSPFR) are examined by using 193-nm photodissociation and post-source decay (PSD) TOF-TOF-MS techniques. The photodissociation apparatus is equipped with a biased activation cell, which allows us to detect fragment ions that are formed by dissociation of short-lived (<1 mus) photo-excited ions. In our previously reported photodissociation studies, the fragment ions were formed from ions dissociating with lifetimes that exceeded 10 mus; thus these earlier photofragment ion spectra and post-source decay (PSD) spectra [composite of both metastable ion (MI) and collision-induced dissociation (CID)] were quite similar. On the other hand, short-lived photo-excited ions dissociate by simple bond cleavage reactions and other high-energy dissociation channels. We also show that product ion types and abundances vary with the location of the charge on the peptide ion. For example, H+ and Na+ cations can bind to multiple polar functional groups (basic amino acid side chains) of the peptide, whereas Cu+ ions preferentially bind to the guanidino group of the arginine side-chain and the N-terminal amine group. Furthermore, when Cu+ is the charge carrier, the abundances of non-sequence informative ions, especially loss of small neutral molecules (H2O and NH3) is decreased for both photofragment ion and PSD spectra relative to that observed for [M + H]+ and [M + Na]+ peptide ions.
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