ReviewCurrent psychiatry reports2006
The genetics of alcohol dependence.
Review in Current psychiatry reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The heritability of alcohol use disorders: a meta-analysis of twin and adoption studies.Psychological medicine · 2015Pooled it
- TACR1 genotypes predict fMRI response to alcohol cues and level of alcohol dependence.Alcoholism, clinical and experimental research · 2013Trial
- Beyond social disorganization: Family SES, neighborhood context, and adolescent alcohol use.SSM - population health · 2026Article
- The Promise of Genetics in Alcohol Use Disorders and the Problems of Phenotype, Polygenetic Architecture, Ancestry, and Comorbidity.The American journal of psychiatry · 2025Article
- FYN Tyrosine Kinase Gene Polymorphisms in Alcohol-Dependent Korean Patients.Alpha psychiatry · 2025Article
- Epigenetic Dysregulation in Alcohol-Associated Behaviors: Preclinical and Clinical Evidence.Current topics in behavioral neurosciences · 2025Review
- Human genetics and epigenetics of alcohol use disorder.The Journal of clinical investigation · 2024Review
- Sex-dependent factors of alcohol and neuroimmune mechanisms.Neurobiology of stress · 2023Article
- Prevalence and heritability of alcohol use disorders in 18-year old Swedish twins.Nordisk alkohol- & narkotikatidskrift : NAT · 2023Article
- Alcohol use disorder as a risk factor for violent offending and reoffending in delinquent women with substance use disorders.Archives of women's mental health · 2023Article
- Genetics of Cardiovascular Disease: How Far Are We from Personalized CVD Risk Prediction and Management?International journal of molecular sciences · 2021Review
- Unpacking Genetic Risk Pathways for College Student Alcohol Consumption: The Mediating Role of Impulsivity.Alcoholism, clinical and experimental research · 2019Article
- Population genomics of wild Chinese rhesus macaques reveals a dynamic demographic history and local adaptation, with implications for biomedical research.GigaScience · 2018Article
- miRNA-regulated transcription associated with mouse strains predisposed to hypnotic effects of ethanol.Brain and behavior · 2018Article
- GABAPsychopharmacology · 2018Review
- Reduced alcohol-seeking in male offspring of sires exposed to alcohol self-administration followed by punishment-imposed abstinence.Pharmacology research & perspectives · 2018Article
- Differences between White and Black young women in the relationship between religious service attendance and alcohol involvement.The American journal on addictions · 2017Article
- NMDA Glutamate Receptor Antagonism and the Heritable Risk for Alcoholism: New Insights from a Study of Nitrous Oxide.The international journal of neuropsychopharmacology · 2017Article
- Impulsivity in rodents with a genetic predisposition for excessive alcohol consumption is associated with a lack of a prospective strategy.Cognitive, affective & behavioral neuroscience · 2017Article
- Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence?Addiction biology · 2016Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Alcohol dependence is a common, complex disorder, which affects millions of people worldwide and causes considerable burden in terms of interpersonal and societal costs. Family, twin, and adoption studies have convincingly demonstrated that genes play an important role in the development of alcohol dependence, with heritability estimates in the range of 50% to 60% for both men and women. A number of studies are under way to identify specific genes involved in the predisposition toward alcohol dependence, and there is reason to be enthusiastic about recent progress. Several associated susceptibility genes are reviewed here, including genes involved in alcohol metabolism, as well as genes involved in GABAergic, endogenous opioid, dopaminergic, cholinergic, and serotonergic transmission. The next challenge will be to further characterize the risk associated with these susceptibility genes, examining how they may be related to comorbid disorders, developmental trajectories of risk, and potential moderation by environmental factors.
Indexed as
Identifiers
16539893What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.