ArticleJournal of muscle research and cell motility2006
Myoinformatics report: myosin regulatory light chain paralogs in the human genome.
Article in Journal of muscle research and cell motility, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 14 citations in OpenAlex.
- Research into the physiology of myosins - a personal odyssey.European journal of translational myology · 2025Article
- Developmental, Physiological and Phylogenetic Perspectives on the Expression and Regulation of Myosin Heavy Chains in Craniofacial Muscles.International journal of molecular sciences · 2024Review
- Structure of the shutdown state of myosin-2.Nature · 2020Article
- Myosin light chain kinase and the role of myosin light chain phosphorylation in skeletal muscle.Archives of biochemistry and biophysics · 2011Review
- Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo.The Journal of biological chemistry · 2010Article
- Regulatory light chain mutations associated with cardiomyopathy affect myosin mechanics and kinetics.Journal of molecular and cellular cardiology · 2009Article
- A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart.The Journal of clinical investigation · 2007Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
On-line bioinformatics tools were used to identify and characterize all paralogs (intragenomic homologs) of muscle myosin regulatory light chains in the human genome. The initial search yielded 22 possible paralogs, but careful examination of supporting data eliminated most of these. Five paralogs were clearly identified with the tissue types (skeletal and cardiac muscles, smooth muscle, non-muscle cytoplasm) in which they are expressed. Sequence comparisons and phylogenetic analysis showed early divergence of a common ancestor of smooth muscle and non-muscle paralogs from a common ancestor of skeletal and cardiac muscle paralogs. An unusual sixth human paralog was very similar to the regulatory light chain of "superfast" myosin, which to date has been found only in cat. Finally, a unique and questionable "precursor lymphocyte" paralog was tentatively identified. Three-dimensional structural models of all seven human paralogs were constructed using the known structure of chicken fast skeletal muscle regulatory light chain as a template.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.